LMCB Director
LMCB Group Leader, Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø Professor of Cell Biology
Co-Chair Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø Cancer Domain
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+44 (0)20 7679 2240
LMCB Room 1.01b
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Cell biogenesis and tissue regeneration
Research synopsis
A regenerative tissue must be able to switch between different states; a stable, functional tissue that remains more or less the same for the lifespan of the animal and a repairing tissue that aims to return to the homeostatic state.ÌýPeripheral nerve is such a tissue; highly quiescent and architecturally stable during adulthood, it retains remarkable regenerative capabilities.
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Critical to this process is the Schwann cell, the major glial cell of the Peripheral Nervous System (PNS). In the adult, Schwann cells are normally quiescent and associated with axons, however, in response to injury, these cells undergo a dramatic change in cell-state to a more progenitor-like state and these cells orchestrate the multicellular response required for nerve regeneration.
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Using a combination of powerful in vitro and in vivo models, advanced imaging technologies and molecular analyses, our lab explores fundamental questions associated with these changes in cell state and how addressing these questions provide insight into pathologies such as cancer, neuropathies and pain. These questions include: How is a stable adult tissue established and maintained? How does a tissue switch to a regenerative state following injury and then return to the homeostatic state? How are regenerative processes such as proliferation, inflammation, cell biogenesis and cell migration co-opted during tumourigenesis?
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Selected publications
Malong L, et al (2023). . Dev Cell, 58(3):174-191.e8, 26 Jan 2023
Stierli S, et al (2019). . Glia, 67(11):2203-2215, 19 Jun 2019
Stierli S, et al (2018). . Development 145, dev170316
Rosenberg NH, et al (2018). . Cell Reports 25 (10) 2755-2765
Cattin AL and Lloyd AC (2016). . Curr Opin Neurobiol. 39:38-46
Cattin AL, et al (2015). . Cell 162(5):1127-39
Lloyd AC (2013). . Cell 154(6) 1194-1205
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Funders
Cancer Research UK
Medical Research Council
Wellcome
Rosetrees Foundation
Worldwide Cancer Research
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Research themes
Tissue homeostasis
Tissue regeneration
Cancer biology
Peripheral nerve biology
Cell biogenesis
Heterotypic and homotypic cell-cell interactions
Cell size control
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Technology
Light microscopy
3D imaging
Translational Research
Bioinformatics
Super-resolution microscopy
Electron Microscopy
In vivo models
Primary culture models
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People
Elizabeth Harford-Wright (Postdoctoral Fellow)
Luke Noon (Research Fellow)
Stella Kouloulia (Research Fellow)
Guillem Modol Caballero (Research Fellow)
Alex Power (PhD Student)
Giulia Casal (PhD Student)
Emma Lloyd (PhD Student)
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Collaborators
Sophie Acton (LMCB, UK)
Antonella Riccio (LMCB, UK)

Robin Ketteler (LMCB, UK)

Bill Richardson (Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø, UK)

Simona Parrinello (Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø, UK)
Adrienne Flanagan (Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø, UK)
Tariq Enver (Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø, UK)

Clare Bennett (Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø, UK)
David Parkinson (Plymouth, UK)
Ricardo Henriques (IGC, Portugal)