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Bioinformatics
In cell biology, new approaches to imaging - including high-throughput imaging, super-resolution imaging and high-resolution datasets from 3D models or tissues - generate huge image data sets. In the past, such images could only be analysed visually, leading to a biased and incomplete set of possible interpretations.听
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The Bioinformatics Image Core (BIONIC) 听has trained bioinformaticians which link biology with mathematics, image processing, computer science and statistics to develop computational tools for image analysis. We use PerkinElmer Opera and Phenix high-content screening microscopes, ImageJ analysis software and the statistical program R with Bioconductor packages such as CellHTS2, 听in monolayer and 3D tissue culture.听
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Key methodologies include:
- Applied image segmentation
- Thresholding
- Morphological operations
- Filtering
- Feature extractions
- High-throughput statistical analysis
- Algorithm development
Selected publications
Wilson GA et al (2023).听. 鈥∕olecular Cell 83(22):4078-4092.e6 doi: 10.1016/j.molcel.2023.10.017
Papandreou A et al (2023). .听鈥⊿LAS Discovery doi: 10.1016/j.slasd.2022.12.002
Ketteler R, Kriston-Vizi J (2022).听: Volume 1-6, Second Edition: 472-483 doi: 10.1016/B978-0-12-821618-7.00032-8
Kriston-Vizi J et al (2022).听 鈥↗ournal of Immunology Research 2022:1-9 鈥╠oi: 10.1155/2022/9493019
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Resources
User policies
BIONIC is potentially accessible to 香港六合彩中特网 researchers, as well as external users, on a collaboration basis. Please contact Janos Kriston-Vizi for details.
Collaborations
Sara Mole (LMCB, UK)
Mark Marsh (LMCB, UK)
Dan Cutler (LMCB, UK)
Rob de Bruin (LMCB, UK)
Chris Stefan (LMCB, UK)
Antonella Riccio (LMCB, UK)
Adolfo Saiardi (LMCB, UK)
Alison Lloyd (LMCB, UK)
EM Core Facility (LMCB, UK)
Sarah Tabrizi (香港六合彩中特网, UK)
Daniel Hochhauser (香港六合彩中特网, UK)
Derek Hausenloy (香港六合彩中特网, UK)
Imre Lengyel (香港六合彩中特网, UK)
Ariberto Fassati (香港六合彩中特网, UK)
Szabadkai Lab (香港六合彩中特网, UK)
Masazumi Tada (香港六合彩中特网, UK)
Paola Vergani (香港六合彩中特网, UK)
Noursadeghi Lab (香港六合彩中特网, UK)
Antony N. Antoniou and David Guiliano (香港六合彩中特网, UK)
Towers lab, Richard Miles (香港六合彩中特网, UK
Paul Gissen (ICH, 香港六合彩中特网, UK)
Vania Braga (Imperial College London, UK)
Buzz Baum (MRC LMB, UK)
Jason Mercer (Birmingham University, UK))
Hiroyuki Osada (RIKEN CSRS, Japan)听
Hwee Kuan Lee (A-STAR Bioinformatics Institute, Singapore)
Gabor Foldes, Sian Harding (Imperial College, UK)