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2024 MSA Research Symposium: Early Stages of MSA: Advancing Diagnostics, Biomarkers, & Interventions

Join us on February 9th, 2024, at the 33 Queen Square Lecture Theatre in the heart of Queen Square, to explore groundbreaking and latest MSA clinical and basic science research.

From diagnostics and biomarkers to drug trials and interventions, the MSA Research Symposium promises a day of discussions and updates, shaping the trajectory of MSA research.听This is where clinical insight meets scientific rigor and industry collaboration. Seize the opportunity to connect with pioneers like Sir John Hardy and Prof Claudio Soto, delve into alpha-synuclein genetics, navigate the intricate pathways of MSA with experts such as Prof Henry Houlden, Prof Sonia Gandhi,听Prof Stephen Gentleman and learn from movement disorders experts like Prof Kailash Bhatia, Prof Michele Hu, Dr Valeria Iodice, Dr Nicola Pavese and Dr Wendi Phillips.

Event organised by Dr Viorica Chelban, 香港六合彩中特网 and the MSA Trust.听

Agenda

9.30-10.00 Registration & Coffee

10.00-10.10 Opening remarks. Prof Sonia Gandhi, Clinical and Movement Neurosciences, 香港六合彩中特网 Queen Square Institute of Neurology听

10:10鈥�11:00 New insights into听alpha-synuclein听genetics and biomarkers

Chair: Prof Sonia Gandhi, Clinical and Movement Neurosciences, 香港六合彩中特网 Queen Square Institute of Neurology听

  • Genetic analysis of synucleinopathies. Sir John Hardy. 香港六合彩中特网 Queen Square Institute of Neurology听听
  • Biochemical, biological and structural studies of alpha-synuclein aggregates in Multiple System Atrophy. Prof听Claudio Soto, University of Texas Medical School, USA听听

11.00-12.15 Alpha-synuclein structure, pathways, and genetic risks in MSA听

Chair: Prof Henry Houlden, 香港六合彩中特网 Queen Square Institute of Neurology听

  • Is Multiple System Atrophy a distinct strain of alpha-synucleinopathy? Prof Stephen Gentleman, Imperial College London, UK听
  • The role of oligodendrocytes in synucleinopathies.听Prof Sonia Gandhi, Clinical and Movement Neurosciences, 香港六合彩中特网 Queen Square Institute of Neurology, UK听
  • Targeting autophagy to counteract alpha-synuclein-related pathology in MSA. Maria Xilouri, Biomedical Research Foundation of the Academy of Athens, Greece.听听
  • Genetic risks in patients presenting with MSA. Dr Viorica Chelban. 香港六合彩中特网 Queen Square Institute of Neurology.听听

12.15-12.30 Refreshments Break

12.30-13.30听MSA research: From patient to bench and back to the patient听

Chair: Dr Christopher Kobylecki, Manchester Centre for Clinical Neurosciences, Salford听

  • Setting-up a biobank for research into neurodegenerative diseases. Amanda Helsegrave. Biomarkers lab, 香港六合彩中特网 Queen Square Institute of Neurology
  • Neuroimaging tools for MSA diagnosis and progression, Nicola Pavese, Newcastle.听听
  • ClearSpeechTogether versus standard NHS speech intervention: A single, mixed method, rater-blinded pilot randomised controlled trial for people living with MSA-C. Prof Anja Lowit, Strathclyde University Glasgow.听听

13.30-14.30听Lunch Break

14.30- 15.45 Diagnosing MSA in early disease stages听听

Chair: Prof Michele Hu, Nuffield Department of Clinical Neurosciences, University of Oxford, UK听听

  • Difficulties in diagnosis of prodromal MSA. Dr Wendi Phillips. Addenbrooke's Hospital, Cambridge, UK听
  • Clinical markers in early MSA disease stages. Dr Yen Goh. 香港六合彩中特网 Queen Square Institute of Neurology, UK
  • MSA mimics in early stages of disease: clinical challenges and pathways to diagnosis. Prof Kailash Bhatia, 香港六合彩中特网 Queen Square Institute of Neurology, UK听
  • The Queen Square Autonomic Prodromal (QSA-PRODROMAL) Study. Dr Valeria Iodice, Department of Brain Repair & Rehabilitation, 香港六合彩中特网 Queen Square Institute of Neurology, UK听

15.45- 16.00 Refreshments Break

16.00-16.30 Ongoing MSA drug trials and latest updates

Chair:听 Prof Nick Wood, 香港六合彩中特网 Queen Square Institute of Neurology, UK听

  • Ampreloxetine for the treatment of nOH in MSA: Clinical Trial Update.听Dr Valeria Iodice, Department of Brain Repair & Rehabilitation, 香港六合彩中特网 Queen Square Institute of Neurology, UK听
  • Antisense Oligonucleotide Therapy for MSA: Horizon Trial Update. IONIS Pharmaceuticals. Katherine Meilleur, IONIS Pharmaceuticals听

16.45- 17.00听Closing Remarks

17.00-18.30 Drinks Reception

Contact

Please contact听eleanor.jarvis@msatrust.org.uk听if you require any additional information.