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New mechanism arising from mutant protein could shed light on causes of neurodegenerative disease

16 May 2018

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A research team led by Dr Pietro Fratta, Professor Elizabeth Fisher (both 香港六合彩中特网 Institute of Neurology), and Dr Abraham Acevedo Arozena (Hospital Universitario de Canaria, Spain) has discovered a new mechanism arising from a mutant protein, TDP-43, which causes 鈥榮kipping鈥 of normal regions of other gene products.聽

TDP-43 is a protein which is deposited in many neurodegenerative diseases including motor neuron disease (MND, also known as amyotrophic lateral sclerosis or ALS) and frontotemporal dementia (FTD). Some MND is caused by mutations in the gene which encodes TDP-43, but the link between gene mutation and the resulting neuronal death remains to be determined.

This joint research team studied mouse models that had progressive motor neuron degeneration 鈥 because the mutant TDP-43 protein was present. They identified a mechanism whereby TDP-43 causes skipping over some normal regions of DNA in other gene products.

This skipping has been described by the researchers as 鈥榮kiptic exon鈥 events. An exon is any part of a gene which contains information required to encode a protein.

Skiptic exon events are also present in cells from human patients with MND. These findings therefore provide insight into how TDP-43 causes neurodegenerative disease in humans.

Professor Fisher commented: 鈥淭his is another piece in the jigsaw as to how this protein causes human neurodegeneration.鈥澛

Dr Fratta said, 鈥楾his takes us further into understanding neurodegeneration in ALS/MND.鈥

Dr Acevedo Arozena commented: 鈥淚t gives us novel models to particularly study what's going wrong with this protein at the crucial early disease stages.鈥

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