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Institute Professor leads cross-disciplinary study on use of glucose in detecting cancer.

9 July 2013

A new technique for detecting cancer by imaging the consumption of sugar with magnetic resonance imaging (MRI) has been unveiled by 香港六合彩中特网 scientists. The study, led by , Chair of MR Neurophysics heralds a breakthrough which could provide a safer and simpler alternative to standard radioactive techniques and enable radiologists to image tumours in greater detail.

According to the Professor Golay, the senior author on the study: 鈥淥ur cross-disciplinary research could allow vulnerable patient groups such as pregnant women and young children to be scanned more regularly, without the risks associated with a dose of radiation.鈥

The new technique, called 鈥榞lucose chemical exchange saturation transfer鈥 (glucoCEST), is based on the fact that tumours consume much more glucose (a type of sugar) than normal, healthy tissues in order to sustain their growth.

The researchers found that sensitising an MRI scanner to glucose uptake caused tumours to appear as bright images on MRI scans of mice.

First author Dr Simon Walker-Samuel, from the 香港六合彩中特网 Centre for Advanced Biomedical Imaging (CABI) said: 鈥淕lucoCEST uses radio waves to magnetically label glucose in the body. This can then be detected in tumours using conventional MRI techniques. The method uses an injection of normal sugar and could offer a cheap, safe alternative to existing methods for detecting tumours, which require the injection of radioactive material.鈥

Professor Mark Lythgoe, Director of CABI and a senior author on the study, said: 鈥淲e can detect cancer using the same sugar content found in half a standard sized chocolate bar. Our research reveals a useful and cost-effective method for imaging cancers using MRI 鈥 a standard imaging technology available in many large hospitals.鈥

He continued: 鈥淚n the future, patients could potentially be scanned in local hospitals, rather than being referred to specialist medical centres.鈥

The study is published in the journal Nature Medicine and trials are now underway to detect glucose in human cancers.

Dr Walker-Samuel added: 鈥淲e have developed a new state-of-the-art imaging technique to visualise and map the location of tumours that will hopefully enable us to assess the efficacy of novel cancer therapies.鈥

The work was supported by public and charitable funding from the National Institute for Health Research University College London Hospitals Biomedical Research Centre, Cancer Research UK, Engineering and Physical Sciences Research Council (EPSRC) and the British Heart Foundation (BHF).

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