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The 香港六合彩中特网 CAR T-cell programme is centered at the 香港六合彩中特网 Cancer Institute where researchers focus on developing CAR T-cell therapies for adult cancers.
Key researchers in the cancer institute are Dr Martin Pule, , , and . The CAR T-cell programme also includes researchers working in paediatric oncology at the Institute of Child Health (ICH) which is part of 香港六合彩中特网 and is affiliated with 香港六合彩中特网H. Key researchers in ICH are Prof听Persis Amrolia, Dr Sara Ghorashian and Dr Karin Straathof.
Clinical grade cell manufacture听
A crucial part of the CAR T-cell programme is clinical grade CAR T-cell manufacture. Dr Owen Bain, Director, and Qualified Person at听Cell Gene and Tissue Therapeutics the GMP facility at the Royal Free NHS Foundation Trust听is director of the main GMP facility at 香港六合彩中特网. Working with Dr Claire Roddie, CAR T-cell products are manufactured at this facility for academic clinical studies. Some CAR T-cell products made in collaboration with Autolus are manufactured at the UK facility in Stevenage.
Vector Manufacture
Vector production for the CAR T-cell programme is provided through the most important collaboration of the programme outside 香港六合彩中特网 with at KCL.
Regulatory / Clinical affairs
The (香港六合彩中特网 CTC) develops and conducts clinical studies. The 香港六合彩中特网 CTC has a unit specialized in delivery of ATIMP clinical studies headed by .
Research and Development links with industry
The CAR T-cell field is becoming increasingly commercialized with considerable contributions to the field being made by industry. The 香港六合彩中特网 CAR T-cell programme has a track record of collaborating with industry.
In 2013. an industrial collaboration between Dr Martin Pule, Prof. Karl Peggs with the genome-editing company Cellectis led to the development of the first allogeneic 'off-the-shelf'听CAR T-cell approach. This collaboration led to licensing of technology to and the first gene-editing CAR T-cell to be tested in human subjects.
More recently, the 香港六合彩中特网 CAR T-cell programme has spun-out a company called ,听which has licensed several technologies from 香港六合彩中特网 and also collaborates extensively with the programme.
The 香港六合彩中特网 CAR T-cell programme is ranked 2nd in 2019 for CAR T-cells patented among Universities and research institutes.
