香港六合彩中特网

XClose

香港六合彩中特网 Cancer Institute

Menu

Martin Pule

Degrees/professional Qualifications with subjects and dates (Maximum 1,000 characters)

  • 2008 Certificate of Specialist Training in Haematology, RCPI听
  • 2007 Fellow Royal College of Pathologists (FRCPath)
  • 1999 US Medical Licensing Examinations Completed 0-518-972-5听
  • 1997 Member Royal College of Physicians in Ireland (MRCP)听听
  • 1995 Medicine 鈥� University College Dublin, MB Bch BAO (Honors)听

听Present and Previous Positions with dates (Maximum 1,000 characters)听

Jan 2011 鈥� Current Senior Lecturer in Haematology University College London听

Director - 香港六合彩中特网 Cancer Institute Chimeric Antigen Receptor Programme听

Jan 2015 鈥� Current Chief Scientific Officer, Autolus Ltd听

听

Jan 2007 鈥� Dec 2010 MRC Clinician Scientist Fellow听听听听听听听听听听听听 University College London听听

听

June 2005 鈥� December 2006 Clinical Lecturer in Haematology University College London听

听

August 2001- May 2005 Traveling Fulbright Scholar and Research Fellow听

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston听

听

July 1998 鈥� June 2001 Haematology Specialist Training, Dublin听

听

Awards and invited talks:听

  • 听香港六合彩中特网 Business award 2015 for the founding of Autolus Ltd听

  • BBSRC Innovator of the year 2016, Most promising Innovator听

  • Since 2015 I have given >50 invited talks including at ASGCT, Cellicon Valley, EHA and Keystone.听听

听

Relevant Current and Recent Research Grants:听

I have only listed grants I am PI of or else very substantial awards:听

  • Moulton Fund: multi-edited CD30 CAR T-cell therapy for r/r Hodgkins Lymphoma. Principle Investigator 2020-2024. Value 拢1.4M听

  • Moulton Fund: EGFRvIII CAR T-cell therapy for glioblastoma Multiforme. Co-Investigator. 2020-2024. Value 拢1.3M听

  • MRC Project grant 鈥淐D21 CAR T-cell therapy for T-ALL鈥�. Principle investigator 2019-2022. Value 拢680k.听

  • MRC DPFS grant 鈥淎 protein-based method for allogeneic CAR T-cell therapy鈥�. Principle investigator 2019-2024. Value 拢2.2M听

  • Wellcome Trust. Health Innovation Fund. 拢2.7M. CAR T-cell therapy of CNS Lymphoma. Principle Investigators. Starting Sept 2016, 4 years.听

  • EU 20/20 scheme. CARAT consortium. Partner. EURO 1M. Next generation CAR T-cell engineering. Started Sept 2016. 5 years.听

  • NIHR i4i. Phase I/II study of CAR19 in relapsed/refractory ALL. Principle Investigator. 拢3.9M. 3.5 years starting Sept. 2015听

  • Innovate UK / BBSRC Consortium. Coordinator. 鈥淟arge-scale production of lentiviral vectors鈥� 拢1.8M. 3 years starting Aug 2015听

  • CRUK Project grant 鈥�EGFRvIII targeting of glioma by CAR T-cells鈥�. 拢180,000 over 3 years starting Sept. 2015.听

  • CRUK Project grant 鈥淭argeting CD160 for immunotherapy of chronic lymphocytic leukaemia鈥�. Pule[PI], 拢160,000 over 2 years.听

  • EU FP7 ATECT 鈥淎dvanced T-cell Engineering鈥� I am coordinator. EU 6 million; 3 million to 香港六合彩中特网.听听

听

Patents Filed/commercialization听

I have filed > 50 patents. In 2020, a review of the CAR T patent landscape, Nature Biotechnology listed me as the #2 global inventor in CAR T (). In 2021, a by the EPO listed me as the #1 inventor of CAR T cell patents at the EPO. Patents I have filed teach amongst many inventions new suicide genes (WO2013153391 and WO2017137759). new receptor types (WO2015052536, WO2016139487), a strategy to target T cell Lymphomas (WO2015132598) and ways of CAR targeting multiple antigens simultaneously (WO2016174407).听

Designs in first in Man studies听

I have designed numerous T cell engineering components which have been tested in human subjects听

Component听

Description听

Study / papers听

14g2a-CD28-OX-Z听

3rd generation CAR recognizing GD2听

Baylor College of Medicine听

Fmc63-CH1CH2-Z听

First generation CAR recognizing CD19听

香港六合彩中特网/Munster (EU funded)听

听

huK666-CD28-Z听

2nd generation humanized CAR recognizing GD2听

CRUK funded study 听

RQR8/4G7-41BB-Z听

Bicistronic suicide gene + 2nd generation CD19 CAR designed for allo use听

Cellectis / Allogene / 香港六合彩中特网 and听听

CnBx21听

Calcineurin mutant renders T cells resistant to Tacrolimus听

Bluebird Bio funded at 香港六合彩中特网 听

CAT-41BB-Z听

Fast off-rate CD19 CAR designed to improve engraftment and reduce tox听

Multiple 香港六合彩中特网 / Autolus and 听

APRIL-HNG-CD28OXZ听

Third generation BCMA/TACI CAR听

听

AUTO3 Cassette听

First bi-cistronic CD19/CD22 co-targeting cassette听

Autolus and 听

AUTO 4 Cassette听

Suicide gene / TRBC1 targeting CAR听

Autolus 听

CAT/9A8 41BB-Z听

Double transduction CD19 fast-off rate CAR with high-sensitivity CD22 CAR听

听

听

Book Chapters - William鈥檚 Haematology (10th edition) 鈥� Chapter on CAR T cells.听

Public engagement听

I collaborated with the animator Greg Foot to create a Ted Ed video 鈥淗ow to bio hack your T cells to fight cancer鈥�. This is available on and has been watched >500,000 times.听

I collaborated with BBC2 to create a documentary detailing CAR T first in man clinical study. This won the 2020 Grierson Award. It is available on , and on the director鈥檚 page on .听

听

Engagement with Industry and Entrepreneurship听

In 2007, I established a collaboration with the genome editing company Cellectis. With their CSO, Andy Scharenberg, we conceived the idea of TAL mediated TCR and CD52 ko, allowing the use of Campath to prevent CAR T rejection. The first-in-man test was at 香港六合彩中特网 (PMID: 28123068). The cassette I developed for this (RQR8/4G7-41BB-Z) is currently in study by Cellectis in B-ALL (NCT02808442), and in DLBCL by Allogene (NCT03939026).听

In 2015, I founded Autolus Ltd a CAR T cell company based in London. Autolus has since floated on the Nasdaq, raised >$500M and currently employs over 300 people and opened 5 clinical studies. Autolus has licensed CAT19-41BB-z, the fast off-rate CD19 CAR I developed at 香港六合彩中特网 and this is now in a phase Ib/II registration study (NCT04404660).听

I am on the scientific advisory board of Mana Therapeutics, a company developing neo TIL therapy for acute myeloid leukemia. I am also on the scientific advisory board of Virocell Therapeutics.听

Selected Publications听

Citations 鈥� 10905; h-index 鈥� 44; ; Orcid id 鈥� 听

听


Roddie C, Dias J, O'Reilly MA, Abbasian M, Cadinanos-Garai A, Vispute K, Bosshard-Carter L, Mitsikakou M, Mehra V, Roddy H, Hartley JA, Spanswick V, Lowe H, Popova B, Clifton-Hadley L, Wheeler G, Olejnik J, Bloor A, Irvine D, Wood L, Marzolini MAV, Domning S, Farzaneh F, Lowdell MW, Linch DC, Pule MA, Peggs KS. J Clin Oncol. 2021 Aug 31:JCO2100917. doi: 10.1200/JCO.21.00917. Online ahead of print. PMID: 34464155


Wawrzyniecka PA, Ibrahim L, Gritti G, Pule MA, Maciocia PM. Leukemia. 2021 Aug 13. doi: 10.1038/s41375-021-01385-0. Online ahead of print. PMID: 34389804


Biasco L, Izotova N, Rivat C, Ghorashian S, Richardson R, Guvenel A, Hough R, Wynn R, Popova B, Lopes A, Pule M, Thrasher AJ, Amrolia PJ. Nat Cancer. 2021 Jun;2(6):629-642. doi: 10.1038/s43018-021-00207-7. Epub 2021 May 24. PMID: 34345830


Agliardi G, Anna Rita Liuzzi AR, Hotblack听 A, De Feo D, N煤帽ez听 N, Stowe CL, Friebel E, Nannini听 F, Rindlisbacher听 L, Roberts TA, Ramasawmy R, Williams IP, Siow BM, Lythgoe MF, Kalber TL, Quezada SA, Pule MA, Tugues S, Straathof K, Becher B. Nat Commun. 2021 Jan 19;12(1):444. doi: 10.1038/s41467-020-20599-x.

. Straathof K, Flutter B, Wallace R, Jain N, Loka N, Depani S, Wright G, Thomas S, Weng-Kit Cheung G, Gileadi T, Stafford S, Kokalaki E, Barton J, Marriott C, Rampling D, Ogunbiyi O, Akarca AU, Marafioti R, Inglott S, Gilmour K, Al-Hajj M, Day W, McHugh K, Biassoni L, Sizer N, Barton C, Edwards D, Dragoni I, Silvester J, Dyer K, Traub S, Elson L ,Brook S, Westwood N, Robson L, Bedi A, Howe K, Barry A, Duncan C, Barone G, Pule M, Anderson J. Sci Transl Med 2020 Nov 25;12(571):eabd6169. doi: 10.1126/scitranslmed.abd6169.

Ghorashian A, Kramer AM, Onuoha A, Wright G, Bartram J, Richardson R, Albon S, Casanovas-Company J, Castro F, Popova B, Villanueva K, Yeung J, Vetharoy W, Guvenel A, Wawrzyniecka PA, Mekkaoui L, Weng-Kit Cheung G, Pinner D, Chu J, Lucchini G, Silva J, Ciocarlie O, Lazareva A, Inglott S, Gilmour KC, Ahsan G, Ferrari M, Manzoor S, Champion K, Brooks T, Lopes A, Hackshaw A, Farzaneh F, Chiesa R, Rao K, Bonney D, Samarasinghe S, Goulden N, Vora A, Veys P, Hough R, Wynn R, Pule MA, Amrolia PJ. Nat Med 2019 Sep;25(9):1408-1414. doi: 10.1038/s41591-019-0549-5.

. Stavrou M, Philip B, Traynor-White C, Davis CG, Onuoha S, Cordoba S, Thomas S, Pule M. Mol Ther. 2018 May 2;26(5):1266-1276. doi: 10.1016/j.ymthe.2018.03.001.

. Lee L, Draper B, Chaplin N, Philip B, Chin M, Galas-Filipowicz D, Onuoha S, Thomas S, Baldan V, Bughda R, Maciocia P, Kokalaki E, Neves MP, Patel D, Rodriguez-Justo M, Francis J, Yong K, Pule M. Blood. 2018 Feb 15;131(7):746-758. doi: 10.1182/blood-2017-05-781351. Epub 2017 Dec 28.

. Maciocia PM, Wawrzyniecka PA, Philip B, Ricciardelli I, Akarca AU, Onuoha SC, Legut M, Cole DK, Sewell AK, Gritti G, Somja J, Piris MA, Peggs KS, Linch DC, Marafioti T, Pule MA. Nat Med. 2017 Dec;23(12):1416-1423. doi: 10.1038/nm.4444. Epub 2017 Nov 13.

Qasim W, Zhan H, Samarasinghe S, Adams S, Amrolia P, Stafford S, Butler K, Rivat C, Wright G, Somana K, Ghorashian S, Pinner D, Ahsan G, Gilmour K, Lucchini G, Inglott S, Mifsud W, Chiesa R, Peggs KS, Chan L, Farzeneh F, Thrasher AJ, Vora A, Pule M, Veys P. Sci Transl Med. 2017 Jan 25;9(374):eaaj2013. doi: 10.1126/scitranslmed.aaj2013.

. Mock U, Nickolay L, Philip B, Cheung GW, Zhan H, Johnston IC, Kaiser AD, Peggs K, Pule M, Thrasher AJ, Qasim W. Cytotherapy. 2016 Aug;18(8):1002-11. doi: 10.1016/j.jcyt.2016.05.009.

. Poirot L, Philip B, Schiffer-Mannioui C, Le Clerre D, Chion-Sotinel I, Derniame S, Potrel P, Bas C, Lemaire L, Galetto R, Lebuhotel C, Eyquem J, Cheung GW, Duclert A, Gouble A, Arnould S, Peggs K, Pule M, Scharenberg AM, Smith J. Cancer Res. 2015 Sep 15;75(18):3853-64. doi: 10.1158/0008-5472.CAN-14-3321. Epub 2015 Jul 16.

. Philip B, Kokalaki E, Mekkaoui L, Thomas S, Straathof K, Flutter B, Marin V, Marafioti T, Chakraverty R, Linch D, Quezada SA, Peggs KS, Pule M. Blood. 2014 Aug 21;124(8):1277-87. doi: 10.1182/blood-2014-01-545020. Epub 2014 Jun 26.

. Rossig C, Pule M, Altvater B, Saiagh S, Wright G, Ghorashian S, Clifton-Hadley L, Champion K, Sattar Z, Popova B, Hackshaw A, Smith P, Roberts T, Biagi E, Dreno B, Rousseau R, Kailayangiri S, Ahlmann M, Hough R, Kremens B, Sauer MG, Veys P, Goulden N, Cummins M, Amrolia PJ. Leukemia. 2017 May;31(5):1087-1095. doi: 10.1038/leu.2017.39. Epub 2017 Jan 27.

Menger L, Sledzinska A, Bergerhoff K, Vargas FA, Smith J, Poirot L, Pule M, Hererro J, Peggs KS, Quezada SA. Cancer Res. 2016 Apr 15;76(8):2087-93. doi: 10.1158/0008-5472.CAN-15-3352.