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Why are we studying this?
Other drugs that could be considered for anxiety, such as benzodiazepines and antipsychotics, may become addictive or have serious side effects. Pregabalin is well tolerated and safe in treating anxiety, but we do not know how well it works with an antidepressant. The results of the study will let doctors give better advice to those that have not seen improvements and want to add a second medication.
How does it work?
Participants in the study will be given study medication to take alongside their antidepressant. This medication will randomly be either pregabalin or an identical placebo tablet that will not contain pregabalin. Participants will take this for just over six months and will be contacted by researchers periodically to check their symptoms. Participants will then be asked to gradually reduce their medication we will monitor for any withdrawal effects.
Who is suitable?听
If you struggle with symptoms of anxiety and have found that antidepressants have not helped, you may be eligible to join the study. We hope around 500 people will take part from all backgrounds of income, education, gender, race, neurodiversity and sexuality, to make the findings as useful as possible.听
How can you participate?
Only some GP practices are participating in the PETRA study, so your practice may not be. If you are interested in participating in the PETRA study, please speak to your GP and read the participant information sheet to make sure you understand what taking part will entail.
If your GP thinks the PETRA study may be right for you, they will need to fill out a referral form and send that to us. You will also need to complete a Permission to Release form to confirm you are happy for your GP practice to give us relevant information. These documents can be found below.
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