香港六合彩中特网

Malaria remains a terrible disease, causing hundreds of thousands of deaths each year, mostly children under the age of five. While vaccines are showing some promise, there remains an urgent need for new, simple, inexpensive medicines that work by killing the parasite in ways that are different from current medicines, so that we can fight the development of resistance.

A research team at the 香港六合彩中特网 School of Pharmacy involving听听and PhD student Yinuo Wang, have helped identify and optimise a new molecule, OSM-S-106, that kills the听Plasmodium falciparum听parasite responsible for most malaria cases. The way in which OSM-S-106 works is new 鈥� it blocks an important part of the machinery in the parasite that makes proteins. In addition, it does so by 鈥渉ijacking鈥� a naturally-occurring biochemical reaction, leading to the formation of a new molecule in the parasite that is a particularly effective 鈥渟panner in the works鈥�.

"This project was a big collaborative effort,鈥� said Professor Todd. 鈥淭he drug discovery aspect was tough 鈥� we were struggling to improve our starting point, but by working with biology teams led by Leann Tilley in Melbourne and Elizabeth Winzeler in San Diego, the molecule鈥檚 beautiful mechanism was gradually revealed, and this provides important clues as to what we should do next. It also raises fascinating questions of how general a mechanism of killing this might be that we could use against other pathogens.鈥�

The project is part of Open Source Malaria () meaning that all data and ideas are online and anyone may participate.听 听听

Yinuo Wang, 香港六合彩中特网 PhD student and joint first author, said 鈥淚t was really fun to be part of this project and I鈥檓 looking forward to exploring what we鈥檝e learned about this molecule."

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