香港六合彩中特网

Set up by Cancer Research UK and the National Cancer Institute in the US (part of the National Institutes of Health), Cancer Grand Challenges aims to drive progress against major research and treatment hurdles, by setting 鈥榗hallenges鈥� and bringing diverse, international teams together to think differently.

Today (June 16), Cancer Grand Challenges announced four new teams of scientific investigators who will each receive 拢20m. 香港六合彩中特网 researchers are represented in three of the four teams and will receive 拢11.97m in total, over the next five years.

Dr Martin Pule (香港六合彩中特网 Cancer Institute) will co-lead the NexTGen team, which takes on the 鈥楽olid tumours in children鈥� challenge. He will be joined by 香港六合彩中特网 co-investigators Professor Karen Page (香港六合彩中特网 Mathematics), Dr Karin Straathof (香港六合彩中特网 Great Ormond Street Institute of Child Health), Professor Sergio Quezada and Dr Kevin Litchfield (both 香港六合彩中特网 Cancer Institute) and Professor Marc-Olivier Coppens (香港六合彩中特网 Chemical Engineering).听

The team, co-led by the US Children鈥檚 National Hospital鈥檚 Catherine Bollard and with 23 investigators across the UK, US and France, will work to develop next-generation immunotherapies for children with solid cancers. This team will be joined by seven patient advocates, including Sara Wakeling, who is a Research Assistant at 香港六合彩中特网 Great Ormond Street Institute of Child Health, and has a particular focus on parental and patient involvement within research.

Dr Pule, who leads the 香港六合彩中特网 CAR-T programme, said: 鈥淭he vision of the Cancer Grand Challenges NexTGen team is that CAR T-cell therapy for solid childhood cancers will be at the front line within a decade, improving outcomes for children with the poorest prognosis and mitigating the toxicities of our current standard of care.

鈥淏y bringing together a critical mass of diverse researchers with a focus on bench to bedside and back again, we believe we鈥檒l overcome current challenges and realise this vision.鈥�

Dr Mariam Jamal Hanjani (香港六合彩中特网 Cancer Institute) has been selected to join two Cancer Grand Challenges teams.

She will be co-investigator on the eDyNAmiC team, which is led by Stanford University and taking on the 鈥榚xtrachromosomal DNA鈥� challenge. The team based in UK, US and Germany, will investigate extrachromosomal DNA 鈥� a major driver of tumour evolution and why some people鈥檚 cancer becomes resistant to treatment 鈥� seeking to find new ways to treat some of the hardest-to-treat cancer types.

Dr Hanjani will also be co-investigator on the CANCAN team, which is led by Rutgers Cancer Institute of New Jersey, Weill Cornell Medicine and Cold Spring Harbor Laboratory and taking on the 鈥榗ancer cachexia鈥� challenge.

With researchers across the UK and US, the team will investigate cancer cachexia 鈥� a debilitating wasting condition people often experience in the later stages of their cancer that imparts a poor prognosis and quality of life 鈥� seeking to develop novel therapies.

鈥淚 feel incredibly honoured and privileged to be part of teams focussed on research that has the potential to significantly impact the lives of the patients with cancer, including the patients I care for,鈥� said Dr Hanjani.

鈥淲e hope that our combined breadth of experience and understanding will allow us to address our Cancer Grand Challenge with an open mind, collaborative effort, mutual respect and overwhelming enthusiasm to make new discoveries and to pave the way forward for a positive impact on patient care and clinical outcomes.鈥澨�听听

Professor Tariq Enver, Director of 香港六合彩中特网 Cancer Institute and Lead听of the CRUK听City of London听Centre, said: 鈥淭his is great recognition for 香港六合彩中特网鈥檚 pioneering scientists who - along with the other successful CRUK City of London researchers - have the boldness, vision and capacity to take on the biggest challenges in cancer. The solutions they discover will hopefully unlock the door to better treatments and secure a better future for all those with cancer.鈥�

Commenting on the awards, Professor Geraint Rees, 香港六合彩中特网 Vice Provost (Research, Innovation and Global Engagement) said: 鈥淭his is an exceptional achievement, and I extend my warmest congratulations to all involved. Cancer affects 1 in 2 people in the UK, and 香港六合彩中特网 is committed to developing new therapies and pioneering ways to improve patient outcomes. This award will make a real difference to the lives of people living with cancer, and demonstrates the value of diverse, cross-disciplinary research.鈥�

The new teams join a growing global community, uniting more than 700 Cancer Grand Challenges researchers and advocates across 10 countries to take on 10 of the toughest challenges in cancer research.

鈥淐ancer is a global issue that needs to be met with global collaboration. This investment in team science encourages diverse thinking to problems that have long hindered research progress,鈥� said David Scott, PhD, Director of Cancer Grand Challenges, Cancer Research UK.

鈥淐ancer Grand Challenges provides the multidisciplinary teams the time, space and funding to foster innovation and a transformative approach. PROMINENT is one of four newly funded teams joining a scientific community addressing unmet clinical needs across cancer research.鈥�

Image

• Top row, Dr Martin Pule, Dr Mariam Jamal Hanjani, Professor Sergio Quezada, middle row, Dr Karin Straathof, Professor Karen Page, bottom row, Dr Kevin Litchfield, Professor Marc-Olivier Coppens. Credit Cancer Grand Challenges

Source

• Adapted from Cancer Grand Challenges announcement

Links

• 听
• 香港六合彩中特网 Cancer Institute
• 香港六合彩中特网 Mathematics
• 香港六合彩中特网 Great Ormond Street Institute of Child Health
• 香港六合彩中特网 Chemical Engineering听

Media contact

Henry Killworth听

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E: h.killworth [at] ucl.ac.uk听