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Description
The overall learning objective for this module is for you to gain knowledge and understanding of the transformation in diagnosis and management of cancer as a result of the ability to predict, prevent and personalise treatment based upon knowledge of each individual patient. This module builds upon the knowledge contained in the Year 2 Cancer Biology and Therapeutics module. This module will consist of a mixture of lectures, interactive tutorials and self-directed learning.
The initial part of the module will focus on defining what is meant by precision cancer medicine and the experimental and diagnostic approaches used in the laboratory and clinic. This may include the role of transcriptomics, genomics, proteomics, epigenomics, metabolomics, molecular imaging or circulating biomarkers.
The focus will then turn to therapeutics. This will be in the form of specific case studies around the underlying biology and rational development of targeted small molecule, biological, cell based or radiotherapy treatments for solid tumours and haematological malignancies. These could include: Gleevec for the treatment of chronic myeloid leukaemia, Herceptin for the treatment of breast cancer, Rituximab for the treatment of lymphomas, or PARP inhibitors in ovarian cancer; the targeting of mutant B-raf in melanoma, epidermal growth factor receptor in lung cancer, or targeted radiotherapy of brain tumours; or the use of antibody drug conjugates, CAR T-cell therapy or Anti-PD-1/PD-L1 therapies.
Module deliveries for 2024/25 academic year
Last updated
This module description was last updated on 19th August 2024.
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