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Description
鈥楳olecular Mechanisms of Gene Expression and Regulation鈥� will convey a broad vision of the contribution of molecular biology to our knowledge of gene regulation in diverse organisms. It will show how molecular biology, when used in conjunction with other biological disciplines (e.g. biochemistry cell biology, genetics) is steadily revealing the mechanisms of previously intractable problems (e.g. control of gene expression). Critical analysis of original experimental data, will be covered in depth, providing the intellectual framework for students to be able to discuss the design of experiments and to justify any conclusions that can be drawn.
After taking this module your knowledge and understanding of molecular biology should have been extended to the point where you can:
- Understand up-to-date principles of experimental design.
- Comprehend the experimental approaches and ideas presented in original scientific papers and reviews.
- Keep abreast of developments in the most topical areas of biology through reading the molecular biological literature
- Critically analyse, appreciate and interpret scientific data and ideas.
Indicative lecture list (based on 2023/24 syllabus)
The structure of genes, the transcriptional machinery and their regulation.
Chromatin structure and dynamics.
XIST regulation.
Epi-transcriptomics and m6A methylation.
mRNA transport and local translation.
Regulation of gene expression by microRNA - molecular mechanisms and networks.
Regulation of mRNA stability and translation.
Cas9 - bacterial immune system, DNA Repair and genome editing, applications
Gene regulation in prokaryotes.
Module deliveries for 2024/25 academic year
Last updated
This module description was last updated on 19th August 2024.
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