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香港六合彩中特网 Institute of Ophthalmology

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Cell image from one of our labs on the cover of long-standing scientific journal

5 June 2024

A recent study from the "Inherited corneal disease lab" at 香港六合彩中特网 Institute of Ophthalmology was selected as the cover image for the May edition of PLOS Genetics.

PLOS Genetics _ Cover

Dr听Nihar Bhattacharyya is a Post-doctoral Fellow in Alice Davidson's team. One of Dr Bhattacharyya' cell images was selected for the cover page of the May听edition of PLOS Genetics cover.听

PLOS Genetics publishes human studies, as well as research on model organisms. The journal's emphasis is on studies of broad interest that provide significant insight into a biological process or processes. Topics include (but are not limited to) gene discovery and function, population genetics, genome projects, comparative and functional genomics, medical genetics, disease biology, evolution, gene expression, complex traits, chromosome biology, and epigenetics.

Image

  • Dual pathways of pathogenicity elicited by a common triplet repeat expansion disease.
    An intronic CTG triplet repeat expansion in the transcription factor gene TCF4 frequently underlies a common age-related corneal disease called Fuchs endothelial corneal dystrophy (FECD). This image depicts two distinct mechanisms of downstream pathogenicity in affected corneal endothelial cells elicited by the repeat: TCF4 isoform dysregulation on the left as visualized via RNAScope staining (white puncta), and toxic repeat-containing RNA foci on the right visualized via fluorescence in situ hybridization (red foci). Image credit: Nihar Bhattacharyya

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