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Dr Mariya Moosajee, consultant ophthalmologist at Moorfields Eye Hospital NHS Foundation Trust and senior clinical lecturer at the 香港六合彩中特网 Institute of Ophthalmology has been awarded 拢1.1m from the Wellcome Trust for a Clinical Research Career Development Fellowship.聽

Stem cells derived from patient鈥檚 skin will be used to grow a 3D model of a human eye to investigate genes that cause ocular maldevelopment, a condition which can cause babies to be born without eyes or underdeveloped eyes. Pioneering gene editing technology will then correct the defective gene to see if the cells can grow into normal healthy eyes.聽

It is hoped that this could pave the way for targeted drug and gene therapies that might one day be used as a prenatal therapy. Birth eye defects develop during pregnancy and cause structural abnormalities in the eye. They are responsible for over a third of blindness and severe visual impairment in children worldwide. Only a few genes have been found to cause the abnormalities and there is no treatment currently available.聽

The funding will allow for full genome screening of patients with birth eye defects to identify the genetic cause of their condition. This will help provide accurate genetic diagnosis in the future, with informed genetic counselling and improved care pathways for patients and their families.聽

Dr Mariya Moosajee said:聽

鈥�鈥淣early twenty percent of all children registered blind in the UK suffer from birth eye defects but only a few genetic causes have so far been identified. Once we understand the genetic causes and can identify chemical changes in human DNA that influence genes being switched on or off at crucial points during normal eye development, a real focus on developing a treatment can be made. It will allow us to develop and test new drugs and targeted genetic therapies that could one day be used to encourage eye growth and prevent the abnormalities from developing.鈥�

Professor Sir Peng Tee Khaw, director of research and development at Moorfields Eye Hospital and director of the NIHR Biomedical Research Centre (BRC) at Moorfields and the 香港六合彩中特网 Institute of Ophthalmology, said:

鈥�鈥淭his is an extremely important and exciting award from the Wellcome Trust to Dr Moosajee. So many of the children we see here at the NIHR Biomedical Research Centre at Moorfields and the 香港六合彩中特网 Institute of Ophthalmology, where we have the largest children鈥檚 eye centre in the world, suffer from these developmental problems. This research will help us to translate this leading science into new understanding and hopefully treatments for these children in the future.鈥�