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Research
Immune therapy
We study immunity to viruses that remain leading global causes of morbidity and mortality: human immunodeficiency virus (HIV), hepatitis B (HBV), cytomegalovirus (CMV) and SARS-CoV-2. By dissecting how these viruses evade host immunity and by distinguishing protective from pathogenic immune responses, we can inform development of urgently needed vaccines and immunotherapies.
Cancer immunology
Antiviral vaccines and therapies
Protective and dysfunctional antiviral immunity
Immune tolerance
We seek to understand more about the mechanisms behind the function of T & B cells, autoimmune diseases, the complexity of the immunity system, and tissue immunity from disease sites. Our aim is to tackle overreaction or erroneous behaviours, and to develop better vaccine designs, biomarkers and targeted immunotherapies.
Autoimmunity and inflammation
Computational immunology
T & B cell development and function
Tissue immunity
Transplantation
Inherited disease
We study inborn errors of immunity (IEI), rare inherited diseases that result in immunodeficiency and/or autoimmunity, inflammation and malignancy. The number of identified genes that cause IEI continues to grow. We aim to explore the mechanisms by which specific gene mutations in IEI cause immunological diseases and use this knowledge to develop new therapies.
