Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø

XClose

Early Phase Cancer Trials Programme at Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø and Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH

Home
Menu

Lung Trials

A list of our early phase Lung CancerÌýtrials which are open to recruitment at University College London Hospitals

To find more information on Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Early Phase Cancer Clinical Trials, including eligibility criteria, click theÌýhyperlinkedÌýLocal Project Reference (LRP)ÌýID, which will take you to the Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Find a Study database.

Additional early phase clinical trials recruiting Lung cohorts may be found in the Advanced Solid Tumour Trials Portfolio page.

Ìý

APL-101-01

Safety and efficacy of APL-101 in NSCLC and advanced solid tumors:Ìý Phase 1 / 2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Local Project Reference:
Principal Investigator:Dr. Martin Forster
Drug Class/ Treatment:APL-101Ìý(C-Met Inhibitor)
Patient Population:Non-Small Cell Lung Cancer (NSCLC)
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF)

FURMO 002

A PHASE 1b DOSE ESCALATION AND DOSE EXPANSION STUDY EVALUATING THE SAFETY, PHARMACOKINETICS, AND ANTITUMOR ACTIVITY OF FURMONERTINIB IN PATIENTS WITH ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER (NSCLC) WITH ACTIVATING EGFR OR HER2 MUTATIONS, INCLUDING EXON 20 INSERTION MUTATIONS

Local Project Reference:
Principal Investigator:Dr Martin Forster
Drug Class/Treatment:

FurmonertinibÌý(EGFR Tyrosine-Kinase Inhibitor)

Patient Population:Non-Small Cell Lung Cancer (NSCLC) with EGFR or HER2 MutationsÌý(Including Exon 20 Insertion Mutations)
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF)

KisMET-01 (MYTX-011-01)

A Phase 1 Multicenter Dose Escalation and Dose Expansion Study of Antibody-DrugConjugate MYTX-011 in Subjects with Non-Small Cell Lung Cancer - KisMET-01

Local Project Reference:
Principal Investigator:Dr Sarah Benafif
Drug Class/Treatment:

MYTX-011Ìý(cMET-Targeted Valine-Citrulline Monomethyl Auristain E (vcMMAE) ADC)

Patient Population:Non-Small Cell Lung Cancer (NSCLC)
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF)

CCR4220: HyPeR

Hyper: A Phase 1, Dose Escalation Study Of SGI-110, A Second-Generation Hypo-Methylating Agent In Combination With Pembrolizumab (MK3475) In Patients With Refractory Solid Tumors

Local Project Reference:Ìý
Principal Investigator:

Dionysis Papadatos-Pastos

Drug Class/Treatment:

ASTX727 (Fixed-dose combination of Decitabine and Cedazuridine) + Pembrolizumab

Patient Population:

Refractory Solid Tumours:

  • NSCLC patients
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF)

Ìý

ATX-NS-001 (CHIRON)

ATX-NS-001 - ATL001 for the Treatment of Non-Small Cell Lung Cancer: ÌýAn open label, multi-centre, phase I/IIa study evaluating the safety and clinical activity of neo-antigen reactive T cells in patients with advanced non-small cell lung cancer (CHIRON)

Local Project Reference:
Principal Investigator:Dr. Martin Forster
Drug Class/ Treatment:ATL001 -ÌýAutologous Clonal Neoantigen Reactive T-Cell (cNeT)
Patient Population:Non-Small Cell Lung Cancer (NSCLC)
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Cancer Clinical Trials Unit (CCTU)

PALOMA-2

A Phase 2, Open-Label, Parallel Cohort Study of Subcutaneous Amivantamab in Multiple Regimens in Patients with Advanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer

Local Project Reference:
Principal Investigator:Dr Sarah Benafif
Drug Class/ Treatment:

Amivantamab (Bi-specific EGF & MET Receptor-Directed Antibody)

Subcutaneous

Patient Population:

Non-Small Cell Lung Cancer (NSCLC):

  • Cohorts 1, 3, 5, and 6 - EGFR Exon19del or Exon 21 L858R mutation
  • Cohort 2 - EGFR Exon20ins mutation
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Cancer Clinical Trials Unit (CCTU)

CONCORDE

A platform study of DNA damage response inhibitors in combination with conventional radiotherapy in non small cell lung cancer

Local Project Reference:
Principal Investigator:Dr. Crispin Hiley
Drug Class/ Treatment:

Radiotherapy + Olaparib (PARP Inhibitor)Ìýor AZD1390 (Oral ATM Inhibitor)

Patient Population:Non-Small Cell Lung Cancer
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Cancer Clinical Trials Unit (CCTU)

Ìý

Ìý

Ìý

Ìý

On-hold to recruitment
LuCa-MERIT-1 (BNT116-01)
LuCa-MERIT-1: First-in-human, open label, Phase I dose confirmation trial evaluating the safety, tolerability and preliminary efficacy of BNT116 alone and in combinations in patients with advanced non-small cell lung cancer
Local Project Reference:161258
Principal Investigator:Dr Sarah Benafif
Drug Class/Treatment:

BNT116Ìý(mRNA Vaccine)

Monotherapy and Combination with Immunotherapies

Patient Population:Non-Small Cell Lung Cancer (NSCLC)
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF)

Ìý