To find more information on Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Early Phase Cancer Clinical Trials, including eligibility criteria, click theÌýhyperlinkedÌýLocal Project Reference (LRP)ÌýID, which will take you to the Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Find a Study database.
Additional early phase clinical trials recruiting Gynae-Oncology cohorts may be found in theÌýAdvanced Solid Tumour Trials Portfolio page.
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R4018-ONC-1721A Phase 1/2 Study of REGN4018 (A MUC16xCD3 Bispecific Antibody) Administered Alone or in Combination with Cemiplimab in Patients with Recurrent Ovarian Cancer | |
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Local Project Reference: | |
Principal Investigator: | Dr Rowan Miller |
Drug Class/Treatment: | REGN4018Ìý(MUC16xCD3 Bispecific Antibody) Monotherpay or Combination with Cemiplimab |
Patient Population: | Recurrent Ovarian Cancer (advanced epithelial ovarian cancer (except carcinosarcoma), primary peritoneal, or fallopian tube cancer) |
Trial Hosted By - NIHR Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF) |
SL03-OHD-105 (REFMAL 721)Phase 1b Study of SL-172154 Administered with Combination Agent(s) in Subjects with Ovarian Cancers:Ìý An Open-Label, Phase 1b Study of SL-172154 (SIRPα-Fc-CD40L) Administered with Either Pegylated Liposomal Doxorubicin or Mirvetuximab Soravtansine in Subjects with Platinum-Resistant Ovarian Cancers | |
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Local Project Reference: | |
Principal Investigator: | Dr Rowan Miller |
Drug Class/Treatment: | SL-172154 (Bi-Functional Fusion Protein targeting CD47) + Perylated Liposomal Doxorubicin or Mirvetuximab Soravtansine |
Patient Population: | Platinum-Resistant Ovarian Cancer |
Trial Hosted By - NIHR Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF) |
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BOUQUET (WO42178)A Phase II, Open-Label, Multicenter, Platform Study Evaluating The Efficacy And Safety Of Biomarker-Driven Therapies In Patients With Persistent Or Recurrent Rare Epithelial Ovarian Tumors | |
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Local Project Reference: | |
Principal Investigator: | Dr. Rowan Miller |
Drug Class/ Treatment: | Platform trial of various Immunotherapy and Targeted Therapy Agents. |
Patient Population: | Persistent Or Recurrent Rare Epithelial Ovarian Tumors |
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Cancer Clinical Trials Unit (CCTU) |
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AZD6738 in Combination With Other Agents in Solid Malignancies (D5330C00004)A Modular Phase I, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of Ascending Doses of AZD6738 in combination with Cytotoxic Chemotherapy and/or DNA Damage Repair/Novel Anti-cancer Agents in Patients with Advanced Solid Malignancies | |
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Local Project Reference: | |
Principal Investigator: | Dr Rowan Miller |
Drug Class/Treatment: | AZD6737 (Ceralasertib) (ATR Kinase Inhibitor)
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Patient Population: | Advanced Solid Tumours:
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Trial Hosted By - NIHR Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF) |
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