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Early Phase Cancer Trials Programme at Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø and Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH

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Gynae-Oncology Trials

A list of our early phase gynae-oncology trials which are open to recruitment at University College London Hospitals

To find more information on Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Early Phase Cancer Clinical Trials, including eligibility criteria, click theÌýhyperlinkedÌýLocal Project Reference (LRP)ÌýID, which will take you to the Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Find a Study database.

Additional early phase clinical trials recruiting Gynae-Oncology cohorts may be found in theÌýAdvanced Solid Tumour Trials Portfolio page.

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R4018-ONC-1721

A Phase 1/2 Study of REGN4018 (A MUC16xCD3 Bispecific Antibody) Administered Alone or in Combination with Cemiplimab in Patients with Recurrent Ovarian Cancer

Local Project Reference:
Principal Investigator:Dr Rowan Miller
Drug Class/Treatment:

REGN4018Ìý(MUC16xCD3 Bispecific Antibody)

Monotherpay or Combination with Cemiplimab

Patient Population:Recurrent Ovarian Cancer (advanced epithelial ovarian cancer (except carcinosarcoma), primary peritoneal, or fallopian tube cancer)
Trial Hosted By - NIHR Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF)

SL03-OHD-105 (REFMAL 721)

Phase 1b Study of SL-172154 Administered with Combination Agent(s) in Subjects with Ovarian Cancers:Ìý An Open-Label, Phase 1b Study of SL-172154 (SIRPα-Fc-CD40L) Administered with Either Pegylated Liposomal Doxorubicin or Mirvetuximab Soravtansine in Subjects with Platinum-Resistant Ovarian Cancers

Local Project Reference:
Principal Investigator:Dr Rowan Miller
Drug Class/Treatment:

SL-172154 (Bi-Functional Fusion Protein targeting CD47) + Perylated Liposomal Doxorubicin or Mirvetuximab Soravtansine

Patient Population:

Platinum-Resistant Ovarian Cancer

Trial Hosted By - NIHR Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF)

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BOUQUET (WO42178)

A Phase II, Open-Label, Multicenter, Platform Study Evaluating The Efficacy And Safety Of Biomarker-Driven Therapies In Patients With Persistent Or Recurrent Rare Epithelial Ovarian Tumors

Local Project Reference:
Principal Investigator:Dr. Rowan Miller
Drug Class/ Treatment:Platform trial of various Immunotherapy and Targeted Therapy Agents.
Patient Population:Persistent Or Recurrent Rare Epithelial Ovarian Tumors
Trial Hosted By - Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Cancer Clinical Trials Unit (CCTU)

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recruitment on-hold

AZD6738 in Combination With Other Agents in Solid Malignancies (D5330C00004)

A Modular Phase I, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of Ascending Doses of AZD6738 in combination with Cytotoxic Chemotherapy and/or DNA Damage Repair/Novel Anti-cancer Agents in Patients with Advanced Solid Malignancies

Local Project Reference:
Principal Investigator:

Dr Rowan Miller

Drug Class/Treatment:

AZD6737 (Ceralasertib) (ATR Kinase Inhibitor)

  • Module 4 - Food Effect Cohort
  • Module 5 - AZD6737 (Ceralasertib)Ìý + AZD5305 (PARP Inhibitor)
Patient Population:

Advanced Solid Tumours:

  • Module 4 - Advanced Solid Tumours
  • Module 5 - High grade epithelial ovarian, fallopian tube, or primary peritoneal cancer.
Trial Hosted By - NIHR Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH Clinical Research Facility (CRF)

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