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Muscle Regeneration for Incontinence
Incontinence is a significant unmet clinical need for adults and children. Regenerative medicine and cell therapy offer听promising solutions to restoring the function of muscles that provide bowel and bladder control. Early clinical studies have reported mixed results, with some studies showing no improvement in muscle function. This is likely due to the cells being delivered in a sub-optimal condition due to their manipulation outside the body and delivery as a suspension, an unnatural state for a muscle cell.
To address this, we have developed听highly porous biodegradable 'TIPS' microcarriers that are used as a surface to attach patients' own muscle cells before delivering them, still anchored to microcarriers, into the defective sphincter muscle. The microcarriers are designed to slowly degrade as the muscle cells integrate with the host muscle, forming new functional tissue that will hopefully restore continence.
Professor Day is leading the 香港六合彩中特网-coordinated AMELIE research project consisting of 13 partners from across 9 countries focussing on the development of the TIPS microcarrier therapy for the treament of faecal incontinence arising from obstetric trauma. The 5 year project started in September 2020 and is funded by the European Union Framework Programme (Horizon 2020). More details are available on the AMELIE project website ().听The project is a pioneering activity for 香港六合彩中特网 and has the potential for major societal impact, as described in this supplement published in The Guardian newspaper听().
Help us听cure incontinence
Your gift makes a difference in supporting our mission to cure incontinence in adults and children. In addition to AMELIE, the Day Lab has multiple projects where we are bringing patients, scientists, and clinicians together to enable innovative collaboration and research. Many of these projects are at an early stage and need funds to enable them to move forward.
As a supporter, your generosity funds innovative, promising research initiatives that might otherwise go unfunded.
You can make a donation towards our pioneering research 听
If you would like further information, please contact Prof Richard Day (r.m.day@ucl.ac.uk)
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People involved:
Professor Richard Day
香港六合彩中特网 Translational Research Office
香港六合彩中特网听European Research听&听Innovation Office
香港六合彩中特网 Comprehensive Clinical Trials Unit
Professor Charles Knowles, Queen Mary University London听
A Novel Medicial Device for Fistula Repair
Fistulas are abnormal connections between two epithelialized surfaces e.g. blood vessels, bladder, intestines, or other hollow organs. The goal of fistula surgery is to close the fistula whilst trying to avoid damage to the surrounding tissue. A range of materials have been used to fill fistulas in an attempt to promote healing but all of these have failed because the material becomes dislodged and falls out or results in an infection.
We are developing novel highly porous microspheres to overcome this problem. When packed into a fistula the microspheres provide a 'scaffold' that cells can easily grow between and into. As the microspheres slowly dissolve they are replaced by new tissue.
Funding from the Wellcome Trust has enabled GMP scale-up of our manufacturing process and testing of the microspheres as a class III medical device (the highest classification for a medical device covering high-risk products that require the greatest level of assessment) in a phase I/II first-in-man clinical safety study at Universit College London Hospital.
The microspheres are 香港六合彩中特网's first biomaterial for regenerative medicine granted approval for clinical use in a regulated device trial by the Medicines and Healthcare Products Regulatory Agency (MHRA).
People involved:
Dr Richard Day
香港六合彩中特网 Translational Research Office
Mr James Crosbie, University College London Hospital
Dr William English,听University College London
Dr Tom Pampiglione,听University College London Hospital
Professor Charles Knowles, University College London / Cleveland Clinic London