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What?听
This research theme will investigate vaccine coverage, efficacy, and safety.
Why?
- Vaccine coverage听will听describe trends and variation in coverage by geographic area, and between key clinical and demographic patient groups.听听听
- Vaccine efficacy will assess the out-of-trial effectiveness of (at least) one dose of a COVID-19 vaccine administered as part of the COVID-19 vaccination programme in England to patients aged 70 and over. The vaccine effectiveness of the Pfizer and AstraZeneca brands will be assessed separately, and in specific clinical subgroups.听
- Vaccine听Safety related work听will investigate prevalence听of blood clots and risk factors for blood clots among COVID-19 vaccine recipients in听England.听The听risk:benefit听assessment of vaccination for younger adults and the risk听of blood clots, transverse myelitis and Bell鈥檚 palsy following COVID-19 vaccination, using听self-controlled听case series and cohort study听designs.听
How?
This will be achieved using听OpenSAFELY听, a听new secure analytics platform for electronic health records in the NHS, created to deliver urgent results during the global COVID-19听emergency听that听is now successfully delivering analyses across more than 58 million patients鈥� full听pseudonymised听primary care NHS records.
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Contacts: Dr Ben Goldacre ben.goldacre@phc.ox.ac.uk, Professor听Ian Douglas Ian.DOUGLAS@lshtm.ac.uk