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香港六合彩中特网 Great Ormond Street Institute of Child Health

Great Ormond Street Institute of Child Health

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Experimental Paediatric Oncology

Principal Investigator, Prof John Anderson

Biography

I was appointed as a Clinical Lecturer in paediatric oncology at 香港六合彩中特网 Great Ormond Street Institute of Child Health (GOS-ICH) in 1998 after completing my PhD in cancer biology, undertaken as a clinical research fellow at the Institute of Cancer Research (1995-1998). My initial 4 year appointment (1998-2002) at GOS-ICH was funded by a donation to ICH from the Great Ormond Street Hospital Special Trustees. In 2001 I was awarded a Cancer Research UK (then the Cancer Research Campaign) Clinician Scientist Fellowship (2002-2007). Since 2007, I have received HEFCE and Great Ormond Street Biomedical Research Centre core funding. In 2005 I gained Certificate of Completion of Specialist Training in Paediatrics and Paediatric Oncology and was appointed as Honorary Consultant Oncologist at Great Ormond Street Hospital.

Research

In 2004, using what was then new the new exciting technology of expression microarrays, we discovered that a gene fusion in aggressive childhood sarcoma called PAX3-FOXO1, confers on tumour cells the ability to avoid detection by the immune system. Since then the research from our group has focussed on identifying ways to overcome immune-suppression and develop effective immunotherapies in childhood solid cancers. Having discovered (2005-2010) that vaccine-type approaches to target candidate childhood solid cancer antigens, generated in general only low affinity and ineffective T cell receptor responses, our research focus shifted to cellular therapies using engineered T cells of both conventional and gamma-delta varieties. Our current focus is on the generation of chimeric receptors for transduction of T cells using novel antibodies with a high degree of specificity for children鈥檚 solid cancers, and with particular interest in fine-tuning of signaling through engineering and drug combination strategies. We were recently awarded approximately 拢9m in research clinical trial grant funding to take two of these products to phase I clinical trial testing.

Currently the group is in receipt of around 拢15m in competitive grant funding from research councils and charities. The work has predominant translational focus whereby clinical observation is used to identify research priorities and opportunities, and the availability of patient populations allows the rapid introduction of innovative treatments in clinical trials. Observations from experimental medicine are also used to generate novel hypothesis to test in the laboratory. The programme encompasses the full translational spectrum from gene discovery, viral and transgene engineering, development and refinement of in vivo models for experimental combination therapeutics, biomarker and imaging development, and GMP implementation.

Collaboration is at the heart of all activity which is reflected in the many partnerships and shared grants with national and international lead resaerchers in the childhood oncology field. Notable grants are the Stand up to Cancer/ CRUK Paediatric Cancer New Discoveries Challenge (($5m), MRC DPFS grant (拢4.2m) to deliver degrader regulated anti-B7H3 CAR-T cells to children with brain tumours, three programme grants joint with ICR and University of Newcastle to develop new combination therapies in children with medulloblastoma, and three project grants to develop switchable CARs using degrader chemistry. Recently we led a shortlisted workpackage for development of degrader regulated CAR-T cells in the latest round of CRUK Cancer Grand Challenges.

香港六合彩中特网 Appointments

  • Professor of Experimental Paediatric Oncology
    University College London, Developmental Biology & Cancer Dept

Degrees

  • Doctor of Philosophy
    University of London, 1998
  • Bachelor of Medicine/Bachelor of Surgery
    University of Newcastle upon Tyne, 1991
  • Bachelor of Arts - Biochemistry
    University of Oxford, 1986

Fields of Research

  • Oncology and carcinogenesis
  • Clinical sciences
  • Immunology
  • Paediatrics
Funders
  • GOSH
  • CRUK
  • Olivia Hodson Cancer Fund
  • European Science Foundation
  • Entertainment Industry Foundation
  • Little Princess Trust
  • Children with Cancer UK
  • Solving Kids Cancer UK
  • Action Medical Research
  • MRC
Recent Publications

2023

Anderson J, . (2023). Molecular Therapy 鈥� Oncolytics, doi: 10.1016/J.OMTO.2023.08.003

Waterhouse DJ, , Anderson J...(2023). Journal of Biomedical Optics, doi: 10.1117/1.JBO.28.9.094804

, Waterhouse DJ, Preziosi A...(2023). Cancer Research, doi:10.1158/0008-5472.CAN-22-2918

Vydra J, Cosimo E, Lesn媒 P鈥�(2023). Clinical Lymphoma, Myeloma & Leukemia, doi:10.1016/J.CLML.2023.02.003

2022

Hont AB, Dumont B, Sutton KS...(2022). Pediatric Blood & Cancer, doi:10.1002/PBC.30110

Halliwell E, Vitali A, Muller H...(2022). Cytotherapy, doi:10.1016/J.JCYT.2022.10.007

Birley K, Leboreiro-Babe C, Rota EM...(2022). Molecular Therapy, doi: 10.1016/J.OMTO.2022.08.008

Berlak M, Tucker E, Dorel M...(2022).听.Molecular Cancer, doi:10.1186/S12943-022-01583-Z

Ferry GM, , Forrester M...(2022). 听Frontiers in Immunology, doi:10.3389/FIMMU.2022.863155

2021听

Coorens TH, Collord G, Lu W, Mitchell E, Ijaz J, Roberts T, Oliver TR, Burke A, Gattens M, Dickens E, ... Anderson J, ... Behjati, S. (2021).听听Blood, doi:10.1182/blood.2020010150

Kildisiute, G., Kholosy, W.M., Young, M.D., Roberts, K., Elmentaite, R., van Hooff, S.R., Pacyna, CN., Khabirova, E., Piapi, A., ...Anderson, J.,听听...Behjati, S. (2021).听听Sci Adv, 7 (6), doi:10.1126/sciadv.abd3311

2020

Pearson, A.D.J., Rossig, C., Lesa, G., Diede, S.J., Weiner, S., Anderson, J.,听Gray J, Geoerger, B., Minard-Colin, V., ...Vassal, G. (2020).听听Eur J Cancer, 127 52-66. doi:10.1016/j.ejca.2019.12.029

Straathof, K., Flutter, B., Wallace, R., Jain, N., Loka, T., Depani, S., Wright, G., Thomas, S., Cheung, GW-K., ...Anderson, J. (2020).听听Science Translational Medicine, doi:10.1126/scitranslmed.abd6169

Gavriil, A., Barisa, M., Halliwell, E., Anderson, J. (2020).听听Cancers, 12 (8), 1-24. doi:10.3390/cancers12082326

Paraboschi, I., De Coppi, P., Stoyanov, D., Anderson, J., Giuliani, S. (2020).听听J Pediatr Surg, doi:10.1016/j.jpedsurg.2020.08.004

Coorens, THH., Farndon, SJ., Mitchell, TJ., Jain, N., Lee, S., Hubank, M., Sebire, N., Anderson, J., Behjati, S. (2020).听听New England Journal of Medicine, 383 (19), 1860-1865. doi:10.1056/NEJMoa2000962

Zormpas-Petridis, K., Poon, E., Clarke, M., Jerome, N.P., Boult, J.K.R., Blackledge, M.D., Carceller, F., Koers, A., Barone, G., ...Anderson, J., ...Jamin, Y.听(2020).听听Cancer Research, doi:10.1158/0008-5472.CAN-20-0133

Grabovska, Y., Mackay, A., O'Hare, P., Crosier, S., Finetti, M., Schwalbe, E.C.,听Pickles, JC., Fairchild, AR., Avery, A., ...Anderson, J.,听 ...Williamson, D. (2020).听听Nat Commun, 11 (1), 4324. doi:10.1038/s41467-020-18070-y

2019

George, S.L., Izquierdo, E., Campbell, J., Koutroumanidou, E., Proszek, P., Jamal, S., Hughes, D., Yuan, L., Marshall, LV., ...Anderson, J., ...听Chesler L.听(2019).听听European Journal of Cancer, doi:10.1016/j.ejca.2019.07.027

Coorens, T.H.H., Treger, T.D., Al-Saadi, R., Moore, L., Tran, M.G.B., Mitchell, T.J.,听Tugnait, S., Thevanesan, C., Young, MD., ...Anderson, J.,听...Behjati S.听(2019).听听Science, 366 (6470), 1247-1251. doi:10.1126/science.aax1323

Nieddu, V., Piredda, R., Bexell, D., Barton, J., Anderson, J., Sebire, N.,听Kolluri, K., Janes, SM., Karteris, E., Sala, A. (2019).听听Oncology Reports, doi:10.3892/or.2019.7152

Fisher, J., Sharma, R., Don, D.W., Barisa, M., Hurtado, M.O., Abramowski, P., Porter, L., Day,听W., Borea, R., Inglott, S., Anderson, J., Pe'er, D. (2019).听听Sci Signal, 12 (598), doi:10.1126/scisignal.aax1872

Barton, J., Pacey, K., Jain, N., Kasia, T., Edwards, D., Thevanesan, C.,Straathof, K., Barone, G., Anderson, J. (2019).听听F1000Res, 8 823. doi:10.12688/f1000research.18209.1

Mahamdallie, S., Yost, S., Poyastro-Pearson, E., Holt, E., Zachariou, A., Seal, S.,听Elliott, A., Clarke, M., Warren-Perry, M., ...Anderson, J.,听听...Rahman, N. (2019).听听Lancet Child Adolesc Health, doi:10.1016/S2352-4642(19)30018-5

Jain, N., Halbert, J., Patel, P.A., Biassoni, L., Anderson, J., Sebire, N., McHugh, K., Barone, G. (2019).听听J Pediatr Hematol Oncol, doi:10.1097/MPH.0000000000001686

Yogev, O., Almeida, G.S., Barker, K.T., George, S.L., Kwok, C., Campbell, J.,听Zarowiecki, M., Kleftogiannis, D., Smith, LM., ...Anderson, J.,听...Chesler, L.听(2019).听听Cancer Research, doi:10.1158/0008-5472.CAN-18-2759

Zormpas-Petridis, K., Jerome, N.P., Blackledge, M.D., Carceller, F., Poon, E., Clarke, M.,听McErlean, CM., Barone, G., Koers, A., ...Anderson, J.,听听...Jamin, Y. (2019).听听Cancer Research, doi:10.1158/0008-5472.CAN-18-3412

Youssef, G., Gillett, C., Rampling, D., Chagtai, T., Virasami, A., Barton, J., Edwards, D., Sebire, N., Anderson, J., Montano, X. (2019).听听Hum Pathol, doi:10.1016/j.humpath.2018.12.003

Oll茅 Hurtado, M., Wolbert, J., Fisher, J., Flutter, B., Stafford, S., Barton, J., Jain, N., Barone, G., Majani, Y., Anderson, J. (2019).听听PLoS One, 14 (8), e0216373. doi:10.1371/journal.pone.0216373

2018

Birley, K., Chester, K., Anderson, J. (2018).听听Current Opinion in Chemical Engineering, 19 153-162. doi:10.1016/j.coche.2018.01.005

Fisher, J., Anderson, J. (2018).听听FRONTIERS IN IMMUNOLOGY, 9 doi:10.3389/fimmu.2018.01409

Wegert, J., Vokuhl, C., Collord, G., Velasco-Herrera, MDC., Farndon, SJ., Guzzo, C., Jorgensen, M., Anderson, J., Slater, O.,听...Behjati, S. (2018).听听NATURE COMMUNICATIONS, 9 doi:10.1038/s41467-018-04650-6

Group members

Dr Marta Barisa
Senior Research Associate听
m.barisa@ucl.ac.uk
香港六合彩中特网 Profiles page:

Ms Courtney听Himsworth
Research Assistant
c.himsworth@ucl.ac.uk
香港六合彩中特网 Profiles page:

Miss Farah Alam
PhD student
farah.alam.20@ucl.ac.uk
香港六合彩中特网 Profiles page:听

Miss Gabrielle Ferry
Research Fellow
gabrielle.ferry.18@ucl.ac.uk
香港六合彩中特网 Profiles page:听

Ms Henrike Muller
PhD student
henrike.muller.16@ucl.ac.uk
香港六合彩中特网 Profiles page:

Ms Marilena Nicolaidou
Research Technician
m.nicolaidou@ucl.ac.uk

Miss Meshael Artuki
PhD student
meshael.alturki.19@ucl.ac.uk
香港六合彩中特网 Profiles page:

Dr Sonia Morlando
Research Fellow
s.morlando@ucl.ac.uk

Ms Sophie听Munnings-Tomes
Research Assistant
s.munnings-tomes@ucl.ac.uk

Previous Lab Members:

Kathleen Birley
Emma Halliwell
Beth Hawkins
Kristen Koopmans
Neha Jane
Artemis Gavriil
Irene Paraboschi
Laura Privitera
Charles 听Agbuduwe
Carla Bautista
Jennifer Frosch
Nisansala听Wisidagamage Don
Alice Vitali
Ilia Leontari
Clara Leboreiro Babe

Professor John Anderson

John Anderson

Professor of Experimental Paediatric Oncology and Honorary Consultant Oncologist
Developmental Biology & Cancer Dept
香港六合彩中特网 GOS Institute of Child Health

Email:听j.anderson@ucl.ac.uk

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