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Editor - Barbara Kramarz
Congratulations to Ruth on her promotion to Professorial Research Fellow!
We are very pleased to announce that Dr Ruth Lovering has been听听to Professorial Research Associate. Ruth has been leading the听Functional Gene Annotation team at 香港六合彩中特网 for the听last ten years. Throughout this decade Ruth has contributed to听听of published knowledge about human proteins and miRNAs and promoted the听teams' work at international听. In line with 香港六合彩中特网's听Connected Curriculum, Ruth has also greatly contributed to teaching at 香港六合彩中特网 by having developed a听ten-week MSc-level听Bioinformatics Resources module as well as a听two-day workshop听open to Health and Life Science researchers at 香港六合彩中特网.听Congratulations, Ruth!
Congratulations on a听new grant to describe the听roles of microRNAs in neuroinflammation
Congratulations to Professor Ruth Lovering (香港六合彩中特网), Dr听Rachael Huntley (香港六合彩中特网) and Professor David Brough (University of Manchester) on having been awarded a听grant (ARUK-NSG2018-003) by听听to capture听published knowledge about microRNAs (miRNAs) implicated in neuroinflammatory processes and to curate the听roles of these miRNAs using Gene Ontology (GO) annotations. MiRNAs involved in regulation of expression of the听microglial proteins听prioritised for GO annotation as a听part of the听protein annotation grant (ARUK-NAS2017A-1) will be curated first. Rachael is a听pioneer in the听field of miRNA GO annotation and she will be the听main curator working on this project. Rachael's key contributions to the听field of miRNA bioinformatics already include the听development of GO guidelines for miRNA annotation () and curation of miRNAs associated with cardiovascular processes (). Rachael has also liaised with curators from different bioinformatics resources, e.g. , or , to ensure that these databases display the听manually-curated GO annotations of miRNAs, which Ruth's team has been contributing. Work on this project will commence on 1st听October 2018.
ARUK-香港六合彩中特网 Gene Ontology annotation progress
Collectively, all of the听ARUK-funded work, has thus far resulted in 4771 GO annotations to 738 gene products, including proteins, microRNAs and macromolecular protein complexes involved in interactions with听amyloid-beta听and听tau听as well as in dementia-relevant听microglial processes. Among these 3338 GO annotations have been associated with 417 human gene products (EBI statistics: 23rd August 2018)
Promoting functional annotation work at 香港六合彩中特网
Barbara's abstract has been selected for a听3-minute flash presentation at the听听on 7th September 2018. Our team is very grateful for this opportunity to introduce the GO resource to the ARUK 香港六合彩中特网 Network community and explain how our work, so relevant in the era of 'Big Data', can help to improve the outcomes of high-throughput dementia research studies. Barbara will also be presenting a听poster at this meeting. Please come to see our poster and talk to Barbara during one of the poster sessions.
Meetings attended
In July Ruth attended another Gene Regulation Ensemble Effort for the Knowledge Commons () meeting in Graz, Austria, which focused on improving ontologies for capturing the role of transcription factors.
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