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Editor - Paul Denny
The 香港六合彩中特网 Gene Annotation team has started a new project, in collaboration between and the (EBI), funded by .
The Project team consists of:
Paul
Denny (Co-ordinator, Biocurator)
Paul has wide experience in genomics, genotyping, sequencing and mouse models of
disease. He has also curated and annotated human genetic variation databases,
and is undergoing intensive training with the Gene Ontology.
Rebecca
Foulger (Biocurator)
Rebecca has extensive experience as both a Gene Ontology (GO) annotator and a GO
editor,
having worked on the GO project for over twelve years. She recently co-ordinated a working group to revise
the signalling domain of GO, and also been involved in outreach activities;
teaching external institutions how to get the most from the Gene Ontology.
Ruth
Lovering (PI)
Ruth has been leading the Gene Annotation team at 香港六合彩中特网 for six years and has considerable
GO annotation experience.
Gene Annotation
We are taking three main approaches to prioritize targets for annotation, based on biological processes that are known to be relevant to Parkinson's disease (PD), proteins that are encoded by genes known to be associated with the risk of developing PD, or the proteins with which those proteins interact. These priorities will evolve in consultation with our grant co-applicant, Prof. John Hardy (香港六合彩中特网) and our Advisory Board. Thirty genes have been chosen based on published linkage or association studies and can be reviewed . A dozen biological processes, including mitophagy, synaptic transmission and the unfolded protein response have been selected for focused annotation efforts. The protein interactions of three key proteins - LRRK2, SNCA and MAPT - are being captured in the database as part of a project funded by the MJ Fox Foundation.聽We are capitalizing on these data by prioritizing the annotation of the same papers that were identified by IntAct; this saves us the time-consuming process of checking the species origin of the proteins.
Gene Ontology
We have also begun the process of improving the Gene Ontology by adding new terms that better describe gene products relevant to Parkinson's disease. We will be guided in this effort by our Advisory Board.
Call for contributions from the Parkinson's Community
We ask scientists and clinicians to review the annotation of their "favourite" gene and suggest what information is missing, incomplete or inaccurate. GO annotations can be viewed in and we welcome suggestions for GO annotations or papers to be used for annotation, by email.
Upcoming events
香港六合彩中特网 Bioinformatics and GO workshop, 1-2 May 2014
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