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Professor Richard Jenner (香港六合彩中特网 Cancer Institute) collaborated with study-lead Professor Graham Lord, (University of Manchester), as part of a 10 year study, looking at the regulatory networks within the immune system.

Published in聽The Journal of Clinical Investigation, the study identifies for the first time聽the molecular pathway that is regulated by a tiny molecular masterswitch - known as microRNA-142.

microRNA-142 controls Regulatory T cells, which modulate the immune system and prevent autoimmune disease. It is, researchers聽found, the most highly expressed regulator in the immune system.

Researchers believe this is a major advance in our understanding of the immune system and could translate into treatments for autoimmune diseases including Cancer, Diabetes, Multiple Sclerosis and Crohn鈥檚 Disease within a few years.

Professor Lord, who led the research while at Kings College London, said: 鈥淎utoimmune diseases often target people in the prime of their life creating a significant socio-economic burden on them. Sometimes, the effect can be devastating, causing terrible hardship and suffering.

鈥淏ut these findings represent a significant step forward in the understanding of the immune system and we believe many people worldwide may benefit.鈥�

If the activity of Regulatory T cells is too low, this can cause other immune cells to attack our own body tissues. If these Regulatory T cells are too active, this leads to suppression of immune responses and can allow cancers to evade the immune system.

So being able to control them is a major step forward in our ability to control- and harness 鈥� the therapeutic power of the immune system.

Professor Richard Jenner, who led the computational side of the project, said that: 鈥淲e were able to trace the molecular fingerprints of this molecule across other genes to determine how it acted as such a critical regulator.鈥�

Professor Lord, now Vice President and Dean of the Faculty of Biology, Medicine and Health at The University of Manchester, added: 鈥淪cientists over the past decade or so have developed therapies which are able to modulate different pathways of the immune system. We hope that this new discovery will lead to the development of new ways to treat autoimmunity, infectious diseases and cancer and we are incredibly excited about where this may lead.鈥�

Further information

• Main image: Electron microscope image of T regulatory cells (red) interacting with antigen-presenting cells (blue).聽颁谤别诲颈迟:听

Media Contact: Henry Killworth
Tel: +44 207 679 5296
E: h.killworth@ucl.ac.uk