香港六合彩中特网

The results of the phase three trial, published in the New England of Journal of Medicine, show that the drug lecanemab works by reducing toxic plaques in the brain known as amyloids. Professor Hardy first highlighted the role of amyloids 30 years ago and his work has shaped our understanding of Alzheimer鈥檚 disease ever since.

When given to patients with early Alzheimer鈥檚 disease, lecanemab not only removed amyloid聽from patients鈥� brains but slowed cognitive decline by about 27% over 18 months.

Professor Hardy hailed the breakthrough as 鈥榯he beginning of the end鈥� of the search聽for Alzheimer鈥檚 treatments.

Commenting on the trial results, he said:

鈥淭his trial is an important first step, and I truly believe it represents the beginning of the end. The amyloid theory has been around for 30 years so this has been a long time coming. It鈥檚 fantastic to receive this confirmation that we鈥檝e been on the right track all along, as these results convincingly demonstrate, for the first time, the link between removing amyloid and slowing the progress of Alzheimer鈥檚 disease.鈥�

Professor Bart De Strooper (UK Dementia Research Institute聽and 香港六合彩中特网 Queen Square Institute of Neurology) said:

鈥淎lzheimer鈥檚 is a complex disease, and we still have a lot to learn about the underlying causes鈥� The overall conclusion is extremely positive. This trial proves that Alzheimer鈥檚 disease can be treated. I hope we will start to see a reversal in the chronic underfunding of dementia research. I look forward to a future where we treat this and other neurodegenerative diseases with a battery of medications adapted to the individual needs of our patients.鈥�

Professor Rob Howard (香港六合彩中特网 Psychiatry) said:聽

鈥淎t long last, we have gained some traction on this most terrible and feared of diseases and the years of research and investment in dementia have finally paid off. It feels momentous and historic. This will encourage real optimism that dementia can be beaten and one day even cured.鈥�

Professor Nick Fox (香港六合彩中特网 Queen Square Institute of Neurology) said:聽

鈥淭his is a very important result and paper鈥� I believe it confirms a new era of disease modification for Alzheimer鈥檚 disease. An era that comes after more than 20 years of hard work on anti-amyloid immunotherapies.鈥�

In an article published today in the Guardian, Professor Jonathan Schott (香港六合彩中特网 Queen Square Institute of Neurology) said:聽

鈥淚t is a remarkable achievement that we now have drugs that have an impact on key underlying biological processes and produce at least some beneficial effects on cognition. As a minimum it establishes that Alzheimer鈥檚 is potentially treatable 鈥� and perhaps one day even preventable, if we could identify and treat individuals who might benefit before symptoms start.鈥�

Related

• 香港六合彩中特网 Queen Square Institute of Neurology
• 香港六合彩中特网 Division of Psychiatry
• UK Dementia Research Institute at 香港六合彩中特网