香港六合彩中特网

Professor Fish and his team at 香港六合彩中特网鈥檚 Drug Discovery Institute have identified a drug candidate that aims to restore the health of the blood-brain barrier in patients with Alzheimer鈥檚 disease.

The blood-brain barrier controls what enters the brain, including glucose, which is essential for providing energy to the brain, and what exits the brain, which is important in the clearance of toxic waste products. Professor Fish has developed a lead molecule that works by inhibiting an enzyme in the brain called NOTUM, which operates aberrantly in some people with Alzheimer鈥檚 disease, and which is essential to the proper development and maintenance of the blood-brain barrier.

Professor Fish is one of two Principal Investigators to receive the award which is given by the Alzheimer鈥檚 Drug Discovery Foundation (ADDF) and Harrington Discovery Institute at University Hospitals in聽Cleveland. 聽

Professor Fish will receive funding and therapeutic development guidance from a team of industry experts to help advance his research towards therapies for patients. Pending successful achievement of developmental milestones, Professor Fish is eligible to receive up to聽$600,000聽in financial support for his work.

Professor Fish said this award will have a big impact in 鈥榮peeding up鈥� the research he is working on: 鈥淗aving worked in drug discovery in a pharmaceutical setting, I am familiar with the significant investment and skills needed to translate our research into a clinical setting for patients. The funding from the ADDF combined with the guidance from a team of industry experts at the Harrington Discovery Institute will perfectly complement our 香港六合彩中特网 project team and collaborators.鈥�

Andrew Pieper, Director, Neurotherapeutics Center, Harrington Discovery Institute, Morley Mather Chair in Neuropsychiatry at University Hospitals and Case Western Reserve University, said: 鈥淲ith Dr Fish, we welcome our first ADDF-Harrington Scholar in the UK. It is exciting to see the growing interest in our program and the high quality of submissions we continue to attract, now internationally.

鈥淲e are well-positioned to identify the most promising discoveries in academic medical centres and help advance them into new medicines for patients with Alzheimer鈥檚 disease.鈥�

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• 香港六合彩中特网 Queen Square Institute of Neurology