香港六合彩中特网

听

New research published in PLOS Biology by Aditya Sethi and Hai Wei (LMU Munich) and Barbara Conradt (香港六合彩中特网 Cell and Developmental Biology) reveals how听novel sequential and reciprocal interactions between the apoptosis pathway and cell size that impact a cell鈥檚 commitment to the cell death fate.

A cell鈥檚 size affects the likelihood that it will die. But how is cell size controlled in this context and how does cell size impact commitment to the cell death fate? The authors听present evidence that the caspase CED-3 interacts with the RhoGEF ECT-2 in Caenorhabditis elegans neuro-blasts that generate 鈥渦nwanted鈥� cells. They propose that this interaction promotes polar acto-myosin contractility, which leads to unequal neuroblast division and the generation of a daughter cell that is below the critical 鈥渓ethal鈥� size threshold. Furthermore, the authors听find that hyper-activation of ECT-2 RhoGEF reduces the sizes of unwanted cells. Importantly, this suppresses the 鈥渃ell death abnormal鈥� phenotype caused by the partial loss of ced-3 caspase and therefore increases the likelihood that unwanted cells die. A putative null mutation of ced-3 caspase, however, is not suppressed, which indicates that cell size affects CED-3 caspase activation and/or activity.

Research article (Open Access):

''. Aditya Sethi, Hai Wei, Nikhil Mishra, Ioannis Segos, Eric J. Lambie, Esther Zanin and Barbara Conradt. PLOS BIOLOGY 06/10/2022听