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The first clinical trial of a Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø-developed biomaterial for tissue regeneration was the FIH phase I/II clinical trial of thermally-induced phase separation (TIPS) microparticles for the treatment of perianal fistulas.

Developed by Division of Medicine’s Dr Richard Day, TIPS provide a scaffold structure that cells can easily grow between and into.

TIPS microspheres are tiny beads the size of a sugar grain that are intended to help wounds to heal. They are made from a material similar to that used for dissolvable stitches and so naturally dissolve inside the body over time.

When packed into a fistula the microspheres should provide a ‘scaffold’ structure that cells can easily grow between and into. As the microspheres slowly dissolve they are replaced by new tissue. 

The clinical translation of TIPS technology, designated a class III medical device, has been supported by the Ïã¸ÛÁùºÏ²ÊÖÐÌØÍøH BRC, Ïã¸ÛÁùºÏ²ÊÖÐÌØÍø TRO and JRO. The knowledge gained in device regulations and manufacture will serve as a foundation for the translation of our significant biomaterials pipeline.