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Predicting Language Outcome and Recovery After Stroke (PLORAS)

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Selected Publications

2022

Bonkhoff AK, Hope T, Bzdok D, Guggisberg AG, Hawe RL, Dukelow SP, Chollet F, Lin DJ, Grefkes C, Bowman H. Recovery after stroke: the severely impaired are a distinct group. J Neurol Neurosurg Psychiatry. 2022 Apr;93(4):369-378. doi: 10.1136/jnnp-2021-327211. Epub 2021 Dec 22. PMID: 34937750.听DOI:听

Geva S, Schneider LM, Khan S, Lorca-Puls DL, Gajardo-Vidal A; PLORAS team; Hope TMH, Green DW, Price CJ. Enhanced left superior parietal activation during successful speech production in patients with left dorsal striatal damage and error-prone neurotypical participants. Cereb Cortex. 2023 Mar 21;33(7):3437-3453. doi: 10.1093/cercor/bhac282. PMID: 35965059; PMCID: PMC10068299.听

Yamamoto AK, Sanju谩n A, Pope R, Parker Jones O, Hope TMH, Prejawa S, Oberhuber M, Mancini L, Ekert JO, Garjardo-Vidal A, Creasey M, Yousry TA, Green DW, Price CJ. The Effect of Right Temporal Lobe Gliomas on Left and Right Hemisphere Neural Processing During Speech Perception and Production Tasks. Front Hum Neurosci. 2022 May 16;16:803163. doi: 10.3389/fnhum.2022.803163. PMID: 35652007; PMCID: PMC9148966.听

RELEASE Collaborators:听Brady MC, Ali M, VandenBerg K, Williams LJ, Williams LR, Abo M, Becker F, Bowen A, Brandenburg C, Breitenstein C, Bruehl S, Copland DA, Cranfill TB, Pietro-Bachmann MD, Enderby P, Fillingham J, Lucia Galli F, Gandolfi M, Glize B, Godecke E, Hawkins N, Hilari K, Hinckley J, Horton S, Howard D, Jaecks P, Jefferies E, Jesus LM, Kambanaros M, Kyoung Kang E, Khedr EM, Pak-Hin Kong A, Kukkonen T, Laganaro M, Lambon Ralph MA, Charlotte Laska A, Leemann B, Leff AP, Lima RR, Lorenz A, MacWhinney B, Shisler Marshall R, Mattioli F, Mavi艧 陌, Meinzer M, Nilipour R, No茅 E, Paik NJ, Palmer R, Papathanasiou I, Patricio B, Pav茫o Martins I, Price C, Prizl Jakovac T, Rochon E, Rose ML, Rosso C, Rubi-Fessen I, Ruiter MB, Snell C, Stahl B, Szaflarski JP, Thomas SA, van de Sandt-Koenderman M, van der Meulen I, Visch-Brink E, Worrall L, Harris Wright H.听Precision rehabilitation for aphasia by patient age, sex, aphasia severity, and time since stroke? A prespecified, systematic review-based, individual participant data, network, subgroup meta-analysis. Int J Stroke. 2022 Dec;17(10):1067-1077. doi: 10.1177/17474930221097477. Epub 2022 May 18. PMID: 35422175; PMCID: PMC9679795.听

2021

Ekert, J.O., Lorca-Puls, D.L., Gajardo-Vidal, A., Crinion, J.T., Hope, T.M.H., Green, D.W. Price, C.P. 2021. A functional dissociation of the left frontal regions that contribute to single word production tasks. Neuroimage. .

Ekert, J.O., Gajardo-Vidal, A., Lorca-Puls, D.L., Hope, T.M.H., Dick, F., Crinion, J.T., Green, D.W., Price, C.J. 2021. Dissociating the functions of three left posterior superior temporal regions that contribute to speech perception and production. Neuroimage (in press).

Ekert, J.O., Kirkman, M.A., Seghier, M.L., Green, D.W.,Price, C.J. 2021. A data-based approach for selecting pre- and intra-operative language mapping tasks. Frontiers in Human Neuroscience (in press).

Geva S, Schneider, L.M., Khan, S., Gajardo-Vidal, A., Lorca-Puls, D.L., PLORAS team, Hope, T.M.H., Green, D.W., Price, C.J. 2021.听Accurate speech production following cerebellar stroke is associated with enhanced activation in cerebral motor regions.听NeuroImage: Clinical.听.

Lorca-Puls, D., Gajardo-Vidal, A., PLORAS team, Oberhuber, M., Prejawa, S, Hope, TMH, Leff, A.P., Green, D.W., Price, C.J. 2021. Brain regions that support accurate speech production after damage to Broca鈥檚 area.听Brain Communications.听.

Geva, S., Schneider, L., Roberts, S., Khan, S., Gajardo-Vidal A.,听Lorca-Puls D., PLORAS team, Hope, T.M.H., Green D.W., Price, C.J. 2021. Right cerebral motor areas that support accurate speech production following damage to cerebellar speech areas. NeuroImage: Clinical. .

Hope, THM., Nardo, D., Holland, R., Ondobaka, S., Akkad, H., Price, CJ., Leff, A.P., Crinion, J.T. 2021. Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study. Scientific Reports.听.

Roberts, S., Bruce, R. M.,听Lim, L., Woodgate, H., Ledingham, K., Anderson, S., Lorca-Puls, D. L., Gajardo-Vidal, A., Leff, A. P., Hope, T. M. H.,听Green, D. W.,听Crinion, J. T.听& Price, C. P. 2021.听Better long-term speech outcomes in stroke survivors who received early clinical speech and language therapy: What鈥檚 driving recovery?听Neuropsychological Rehabilitation.听.

Lorca-Puls DL, Gajardo-Vidal A, Green DW, Price CJ. 2021. Reply: Where is the speech production area? Evidence from direct cortical electrical stimulation mapping. 叠谤补颈苍.听

Geva, S., Schneider, L., Roberts, S., Green D.W., Price, CJ. 2021. The effect of focal damage to the right medial posterior cerebellum on word and sentence comprehension and production. Frontiers Human Neuroscience.听.

Sajid, N., Holmes, E., Hope, T.M., Fountas, Z, Price, C.J. and Friston, K.J. 2021. Simulating lesion-dependent functional recovery mechanisms. Scientific Reports.听.

RELEASE Collaboration. 2021. Predictors of post-stroke aphasia recovery: a systematic review-informed individual participant data (IPD) meta-analysis. 厂迟谤辞办别.听.

Geva, S., Truneh, T., Seghier, M.L, Hope T.M.H., Leff, A.P., Crinion, J.T., Gajardo-Vidal A., Lorca-Puls D.L., Green D.W., PLORAS team, Price, CJ. 2021. Lesions that do and do not impair digit span: A study of 816 stroke survivors.听Brain Communications.听.

Bowman H., Bonkhoff , A., Hope TMH, Grefkes C., Price C.J. 2021. Inflated Estimates of Proportional Recovery from Stroke: The Dangers of Mathematical Coupling and Compression to Ceiling.听厂迟谤辞办别.听.

Gajardo-Vidal A., Lorca-Puls D.L., PLORAS team, Warner H., Bawan, P., Crinion, J.T., Leff, A.P., Hope T.M.H., Geva, S., Seghier, M., Green D.W., Bowman, H., Price, CJ. 2021. Damage to Broca's area does not contribute to long-term speech production outcome after stroke. Brain. .

2020

Upton, E. & Hope, T.M.H. 2020. Moving beyond the dual stream account of language. 叠谤补颈苍.听.

Hope, T.M.H. 2020.听Linear regression. 鈥淢achine Learning: Methods and Applications to Brain Disorders鈥�, Vieira, S. & Mechelli, A. (eds), Chapter 4. Elsevier. ISBN-13: 9780128157398, 978-0128157398.听

Bonkhoff, A., Hope, T.M.H., Bzdok, D., Guggisberg, A.G., Hawe, R.L., Dukelow, S.P., Rehme, A.K., Fink, G.R., Grefkes, C. & Bowman, H. 2020. Bringing proportional recovery into proportion: Bayesian hierarchical modelling of post-stroke motor performance. 叠谤补颈苍.听.

Fleming, V., Brownsett, S., Krason, A., Price, C.J., Crinion, J.T. &听Leff, A.P. 2020. Efficacy of spoken word comprehension therapy in patients with chronic aphasia: A cross-over randomised controlled trial with structural imaging. Journal of Neurology, Neurosurgery and Psychiatry. .

Schevenels, K., Price, C. J., Zink, I., De Smedt, B., & Vandermosten, M. 2020. A review on treatment related brain changes in aphasia. Neurobiology of Language.听.

RELEASE Collaboration. 2020. Communicating simply, but not too simply: Reporting of participants and speech and language interventions for aphasia after stroke.听Int J Speech Lang Pathol.听.

Brady, M., Myzoon, A., VandenBerg, K., Williams, L.J. Williams, L.R. and the RELEASE听Collaboration. 2020. RELEASE: A protocol for a systematic review based, individual participant data meta- and network meta-analysis, of complex speech-language therapy听interventions for stroke-related aphasia.听础辫丑补蝉颈辞濒辞驳测.听.

Twomey, T., Price, C.J., Waters, D., MacSweeney, M. 2020. The impact of early language exposure on the neural system supporting language in deaf and hearing adults. 狈别耻谤辞滨尘补驳别.听.

Sajid N, Parr T, Gajardo-Vidal A, Price CJ, Friston KJ. 2020. Paradoxical lesions, plasticity and active inference. Brain Commun. .

Sajid N, Friston KJ, Ekert JO, Price CJ, W Green D. 2020. Neuromodulatory Control and Language Recovery in Bilingual Aphasia: An Active Inference Approach. Behav Sci (Basel). .

Sajid, N., Parr, T., Hope, T.M., Price, C.J., Friston, K.J. 2020. Degeneracy and Redundancy in Active Inference. Cerebral Cortex.听.

Friston, K.J., Sajid, N., Quiroga-Martinez, D.R., Price, C.J., Holmes, E. 2020. Active listening. Hearing Research.

Friston, K.J., Parr, T., Yufik, Y., Price, C.J., Holmes, E. 2020. Generative models, linguistic communication and active inference.听Neuroscience and Biobehavioral Reviews.听.

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizeau J, Hulme OJ, Billig AJ, Litvak V, Price CJ, Moran RJ, Costello A, Pillay D, Lambert C. 2020. Effective immunity and second waves: a dynamic causal modelling study.听Wellcome Open Research.

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizeau J, Hulme OJ, Billig AJ, Litvak V, Moran RJ, Price CJ, Lambert C. 2020.听Dynamic causal modelling of COVID-19. Wellcome Open Research.听.

2019

Loughnan, R., Lorca-Puls, D. L., Gajardo-Vidal, A., Espejo-Videla, V., Gillebert, C. R., Mantini, D., Price, C.J., Hope, T. M. H. 2019.听Generalizing post-stroke prognoses from research data to clinical data.听Neuroimage: Clinical.听.

Evans S, Price CJ, Diedrichsen J, Gutierrez-Sigut E, MacSweeney M. Sign and Speech Share听Partially Overlapping Conceptual Representations. 2019. Curr Biol. .

Yamamoto AK, Parker Jones O, Hope TMH, Prejawa S, Oberhuber M, Ludersdorfer P, Yousry TA, Green DW, Price CJ. 2019. A special role for the right posterior superior temporal sulcus during speech production. Neuroimage. .

Yamamoto AK, Magerkurth J, Mancini L, White MJ, Miserocchi A, McEvoy AW, Appleby I, Micallef C, Thornton JS, Price CJ, Weiskopf N, Yousry TA. 2019. Acquisition of sensorimotor fMRI under general anaesthesia: Assessment of feasibility, the BOLD response and clinical utility. Neuroimage Clin. .

Zeidman P, Jafarian A, Corbin N, Seghier ML, Razi A, Price CJ, Friston KJ. 2019. A guide to group effective connectivity analysis, part 1: First level analysis with DCM for fMRI. Neuroimage. .

Zeidman P, Jafarian A, Seghier ML, Litvak V, Cagnan H, Price CJ, Friston KJ. 2019. A guide to group effective connectivity analysis, part 2: Second level analysis with PEB. Neuroimage. .

Ludersdorfer P, Price CJ, Kawabata Duncan KJ, DeDuck K, Neufeld NH, Seghier ML. 2019. Dissociating the functions of superior and inferior parts of the left ventral occipito-temporal cortex during visual word and object processing. 狈别耻谤辞颈尘补驳别.听.

2018

Hope, T.M.H., Friston, K.J.,听Price, C.J.,听Leff, A., Rotstein, P.听 & Bowman, H. 2018. 听Brain, 142 (1), 15-22.

Gajardo-Vidal, A., Lorca-Puls, D.L., Hope, T.M.H., Parker Jones, O., Seghier, M.L., Oberhuber, M., Prejawa, S., Crinion, J., Leff, A.P., Green, D.W. &听Price, C.J.听2018.听听Brain, 141 (12), 3389-3404.听

Hope, T.M.H., Leff, A.P. &听Price, C.J. 2018. Neuroimage: Clinical, 19, 22-29.

Seghier, M.L. &听Price, C.J. 2018.听听Trends in Cognitive Sciences,听22, 517-530.

Lorca-Puls, D., Gajardo-Vidal, A., White, J., Seghier, M., Leff, A., Green, D., Crinion, J., Ludersdorfer, P., Hope, T., Bowman, H. &听Price, C.J. 2018. 听Neuropsychologia, 115, 101-111.

Gajardo-Vidal, A., Lorca-Puls, D.L., Crinion, J.T., White, J., Seghier, M.L., Leff, A.P., Hope, T.M.H., Ludersdorfer, P., Green, D.W., Bowman, H. &听Price, CJ.听 2018. 听Neuropsychologia,听115, 124-133.

Aguilar, O.M., Kerry, S.J., Ong, Y-H, Callaghan, M.F., Crinion, J., Woodhead, Z.V.J., Price, C.J., Leff, A.P. &听Hope, T.M.H. 2018.听听Journal of Neurology, Neurosurgery, and Psychiatry,听89 (12), 1352-1354.

Price, C.J. 2018.听听Cortex, 107, 37-49.

2017

Nardo, D., Holland, R., Leff, A.P., Price, C.J. &听Crinion, J.T.听2017.听听 Brain, 140, 3039-3054.

Achilles, E.I.S., Weiss, P.H., Fink, G.R., Binder, E., Price, C.J. &听Hope, T.M.H. 2017. 听 Neuroimage, 161, 94-103.

Woodhead, Z.V.J., Crinion, J., Penny, W., Teki, S., Price, C.J. &听Leff, A.P. 2017. 听Journal of Neurology, Neurosurgery, and Psychiatry, 88, 586-594.

Hope, T.M.H., Leff, A.P., Prejawa, S., Bruce, R., Haigh, Z., Lim, L., Ramsden, S., Oberhuber, M., Ludersdorfer, P., Crinion, J., Seghier, M.L. &听Price C.J. 2017. Brain, 140听(6), 1718-1728.

Lorca-Puls, D.L., Gajardo-Vidal, A., Seghier, M.L., Leff, A.P., Sethi, V., Prejawa, S., Hope, T.M.H., Devlin, J.T. and Price, C.J. 2017.听 Brain,听140听(6),听1729-1742.

Price, C.J., Hope, T.M., Seghier, M.L. 2017.听 Neuroimage, 145听(B),听200-208.

2016

Hope, T.M., Seghier, M.L., Prejawa, S., Leff, A.P., Price, C.J. 2016.听 Neuroimage,听125,听1169-1173.

Seghier, M.L., Patel, E., Prejawa, S., Ramsden, S., Selmer, A., Lim, L., Browne, R., Rae, J., Haigh, Z., Ezekiel, D., Hope, T.M., Leff, A.P., Price, C.J. 2016.听听Neuroimage,听124听(B),听1208-1212.

2015

Hope, T.M., Parker Jones, O., Grogan, A., Crinion, J., Rae, J., Ruffle, L., Leff, A.P., Seghier, M.L., Price, C.J., Green, D.W. 2015.听听Brain, 1-14.

2014

Seghier, M.L., Ramsden, S., Lim, L., Leff, A. P. and Price, C. 2014.听听Stroke,听45, 877-879.

2013

Hope, T., Seghier M., Leff, A. and Price, C. 2013.听听NeuroImage: Clinical, 2听(1), 424-433.

Overview

  • This paper presents a听method that combines听the听influence of stroke,听time post stroke听and听demographic information听in a large group of stroke patients to听predict听the likely course of recovery over time听in new patients.

2010

Ambridge, L., Leff, A., Crinion, J., and Price, C. October 2010.听Predicting language outcome and recovery after stroke.听Royal College of Speech & Language Therapists Bulletin, 12-15.听

Overview

  • This article was written for the听Royal College of Speech & Language Therapists Bulletin. 听
  • It gives an听overview听of the听reasons for the project, the听methods听used, and some听findings.

Price, C., Seghier, M., and Leff, A. 2010.听听Nature Reviews Neurology,听6,听202-210.

Overview

  • This paper presents a听new approach for predicting language outcome and recovery听after stroke.
  • It听compares the practicality of two different possibilities.
  • The听initial perspective听was to听understand the neural circuits that support language听(the wiring in the brain) but this is a complicated endeavour.
  • The听new method听is听more pragmatic听and听makes predictions on the basis of the recovery of previous patients with the same type of stroke.
  • This method听requires a database听that听records the speech and language skills of a large group of patients听who have a听range of stroke sites.听
  • It also听requires a very precise and accurate way of measuring the location and extent of the lesion听in听three dimensional high definition space.

Price, C., Crinion, J., Leff, A., Richardson, F., Schofield, T., Prejawa, S., Ramsden, S., Gazarian, K., Lawrence, M., Ambridge, L., Andric, M., Small, S. and Seghier, M.听2010.听Lesion sites that predict the ability to gesture how an object is used.听Archives Italiennes de Biologie,听148(3), 243-258.

Overview

  • This study combined three methodologies to identify听the听brain regions where damage impairs the ability to gesture how an object听is moved听while preserving the ability to recognise听the object and move the hands.
  • The results demonstrate that听the mapping between lesion site and symptoms is not听one-to-one, because听different lesion sites can cause the same symptom and different symptoms can result from the same lesion site, depending on the degree of damage to other areas. 听For example, the effect of losing the use of your index finger depends on whether or not the other fingers can still be used.
  • The take home message is that predicting outcome from lesion sites requires a consideration of听the combination of regions that听are damaged.

2008

Seghier, M., Ramlackhansingh, A., Crinion, J., Leff, A. and Price, C. 2008.听听Neuroimage,听41, 1253.

Overview

  • This paper introduces a听new procedure for identifying stroke sites听from MRI scan images of the brain.听
  • This procedure is able to听detect stroke sites with different sizes, locations, and textures.听
  • The approach can听help to explain how different stroke sites affect behaviour听of a stroke survivor (such as language skills)听
  • The method should help to听find the total volume of the stroke site听or to听find the exact boundaries of the stroke. 听This听could be useful for surgical purposes听or听diagnosing problems.

2002

Price, C. and Friston, K. 2002.听Degeneracy and cognitive anatomy.听Trends in Cognitive Sciences,听6(10), 416-421. 听. 听Contact Us听for the full text.

Overview

  • This paper was听fundamental in shaping our approach to understanding the relationship between lesion site and cognitive deficit.
  • The听core idea听is that听the brain has different ways of doing the same thing. This is听similar听to听knowing that it is possible to write using either the left or the right hand. If we听lose the left hand, we become听more reliant on the right hand, and if we lose the right hand, we can use our left hand (with practice).
  • These听alternative ways of doing the same thing are available in the healthy brain (or body) but there are a limited number of options.听 For example, if you听lose the use of both your right and left hand听then you may need to听learn to write with a pen in your mouth or your toes.听 There are not an infinite number of viable options and the alternative possibilities may be laborious.听
  • Recovery therefore depends on the availability of efficient options.听
  • In terms of methodology, the paper proposes a way to听understand and delineate the sets of brain regions that can support a particular function.听听
  • However, as described in more recent papers (see above), we now think that it ismore effective to predict outcome and recovery using a pragmatic database approach as opposed to understanding all the underlying theory.听
  • Likewise, although it is听important that you know that your car won't start if the engine's battery is dead, a听driver does not need to know how the battery or the engine work.