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Research News
15 September 2015
Over the last year the Institute of Ophthalmology has been awarded funding for 70 research projects, worth almost 拢14.5 million. We would like to thank all of the organisations that support our research and congratulate the Institute researchers whose hard work is recognised by these awards.
A full list of new projects is shown below.
| Lead | Value 拢 | Funder | Title | |
| Stockman, Prof Andrew | 49,112 | National institute for health research | Genotyping phenotyping and informatics | |
| Davidson, Dr Alice | 200,000 | Fight for sight | Genetic and molecular dissection of corneal endothelial dystrophies | |
| Pearson, Dr Rachael | 100,000 | Fight for sight | Do chondroitin sulphate proteoglycans in the diseased retina impair transplanted photoreceptor migration by inhibiting integrin signalling? | |
| Webster, Prof Andrew | 100,000 | Fight for sight | An investigation of the molecular pathology of developmental macular dystrophies | |
| van der Spuy, Dr Jacqui | 63,524 | Rp fighting blindness | Supporting the triage of lca patients for aip1-targeted gene therapy through the functional valildation of uncharacterised and novel aipl1 variants | |
| Luthert, Prof Philip | 10,000 | Moorfields eye charity | Fluid mechanisms of choroidal circulation | |
| Greenwood, Prof John | 30,000 | Stoneygate trust | Investigation of the potential protective effect of statins on neurovascular and neuronal function | |
| Greenwood, Prof John | 30,000 | Rosetrees trust | Investigation of the potential protective effect of statins on neurovascular and neuronal function in the context of secondary progressive multiple sclerosis | |
| Stockman, Prof Andrew | 501,464 | BBSRC | At and beyond the neural limits: visual psychophysics using an adaptive -optics visual stimulator | |
| Bailly, Dr Maryse | 34,392 | Moorfields eye hospital special trustees | The role of cellular stress in adipogenesis in thyroid eye disease (ted) | 听 |
| Hardcastle, Prof Alison | 60,000 | Moorfields eye charity | Corneal dystrophy genetics | 听 |
| Hardcastle, Prof Alison | 128,083 | Moorfields eye hospital special trustees | Genetic mechanism of disease for x-linked retinal degenerations; characterising a new locus | 听 |
| Bainbridge, Prof James | 50,638 | Moorfields eye hospital special trustees | Investigating the role of myeloid cell hifs in retinal neovascularization | 听 |
| Gazzard, Mr. Gus | 59,482 | British council for prevention of blindness | Health-related quality of life in two treatment pathways for newly diagnosed open angle glaucoma and ocular hypertension in china: an unmasked randomised controlled trial of initial selective laser trapeculoplasty versus conventional medica | 听 |
| Lengyel, Dr Imre | 621,488 | European commission horizon 2020 | Eye-risk exploring the combined role of genetic and non genetic factors developing age-related macular degeneration: a systems level analysis of disease subgroups, risk factors, and pathways | 听 |
| Levine, Dr Tim | 69,624 | BBSRC | Delivering structural bioinformatics to the yeast community with the HHPRY database | |
| Michaelides, Prof Michel | 33,063 | Moorfields eye hospital special trustees | Assessing retinal structure and function longitudinally in Stargardt disease using in-depth advanced phenotyping | 听 |
| Moss, Prof Stephen | 440,269 | MRC | Lipofuscin and the complement system in retinal pigment epithelial cell biology | |
| Ohnuma, Prof Shin-Ichi | 4,000 | Great Britain Sasakawa foundation | In the footsteps of the pioneers : starting new dialogues | 听 |
| Stockman, Prof Andrew | 18,360 | Fight for sight | Imaging fundus reflectometry for amd research and diagnosis: project update | 听 |
| Limb, Prof Astrid | 60,563 | Moorfields eye charity | Neurotrophin expression profile of human muller glia and its implications for rgc survival and neural regeneration of the retina | 听 |
| Daniels, Prof Julie | 37,322 | Moorfields eye charity | Equipment purchase to support stem cell research programme | 听 |
| Garway-Heath, Prof Ted | 36,697 | National institute for health research biomedical | Theme 5: visual assessment and imaging | 听 |
| Ohnuma, Prof Shin-Ichi | 314,783 | Moorfields eye hospital special trustees | Identification and characterisation of novel genes that influence progression and malignancy of retinoblastoma | 听 |
| Ali, Prof Robin | 2,986,496 | MRC | Clinical trial of gene therapy for the treatment of leber congenital amaurosis | |
| Eden, Dr Emily | 432,760 | MRC | Formation and function of membrane contact sites between the er and the | |
| Keane, Dr Pearse | 977,071 | National institute for health research | Binocular OCT - reinventing the eye examination | 听 |
| Carandini, Prof Matteo | 250,000 | Wellcome trust | Decisions and dopamine in frontal cortical circuits | 听 |
| Hardcastle, Prof Alison | 249,910 | Moorfields eye charity | Probing rp2 mechanisms of disease using patient ips cells | 听 |
| Ruhrberg, Prof Christiana | 100,855 | British heart foundation | Defining the role of neuropilin 1 (nrp1) in vascular permeability | 听 |
| Sivaprasad, Miss Sobha | 79,000 | Fight for sight | Structure-function correlation in age related maculopathy | 听 |
| Carr, Dr Amanda | 53,898 | Macular disease society | Using induced pluripotent stem cells to investigate bestrophin associated macular degeneration | 听 |
| Ali, Prof Robin | 60,000 | Batten disease family association | Gene therapy to treat visual failure in NCL | 听 |
| Charoy, Dr Camille | 26,250 | International brain research organization | Establishment of left-right asymmetry in developing nervous system | 听 |
| Pearson, Dr Rachael | 171,429 | Macula vision research foundation | Retinal repair using embryonic stem cell derived photoreceptors: defining the window of transplantation competence | 听 |
| Dart, Mr. John | 15,500 | Moorfields eye charity | The role of interleukin - 13 in the pathogenesis of ocular MMP | 听 |
| Dart, Mr. John | 9,000 | Moorfields eye charity | Autoantigen & genetic determinants of disease in mucous membrane pemphigoid | 听 |
| Ali, Prof Robin | 1,101,688 | MRC | Optimisation of human esc-derived photoreceptor cell differentiation | |
| Bhattacharya, Prof Shomi | 30,407 | Moorfields eye hospital special trustees | Role of spata13 in angle closure glaucoma | 听 |
| Coffey, Prof Pete | 1,588,330 | MRC | Scalable production of RPE cells from induced pluripotent stem cell under GMP | |
| Greenwood, Prof John | 45,000 | Rosetrees trust | Identification and validation of vascular therapeutic targets for the treatment of retinal disease | 听 |
| Hardcastle, Prof Alison | 56,000 | National institute for health research | Funding for consumables associated with corneal genetic studies and your collaborative work with Mr Steve Tuft | 听 |
| Pearson, Dr Rachael | 46,822 | Moorfields eye hospital special trustees | Modulating gliosis to improve photoreceptor transplantation outcome in the diseased retina | 听 |
| Webster, Prof Andrew | 45,400 | National institute for health research biomedical | Brc2_048 research funding award for rare diseases (Stargardt disease) | 听 |
| Stockman, Prof Andrew | 416,283 | BBSRC | Multiple signals interact in flicker: recursive surround networks | |
| Murdoch, Mr. Ian | 30,000 | International glaucoma association | Primary glaucoma treatment trial in Kenya and South Africa - slt vs medication | 听 |
| Lengyel, Dr Imre | 58,850 | Optos plc | The relationship of peripheral retinal deposits in age related macular degeneration and Alzheimers disease | 听 |
| Dart, Mr. John | 14,550 | Fight for sight | A contemporary epidemiological case control study of acanthamoeba keratitis in the uk | 听 |
| Dick, Prof Andrew | 15,000 | Fight for sight | Investigation of annexin-a1 expression in healthy and uveitis ocular tissue | 听 |
| Greenwood, Prof John | 93,746 | Innovate uk | Evaluating novel monoclonal antibodies to target adam 15 for a potential novel ocular anti angiogenesis therapy | 听 |
| Hardcastle, Prof Alison | 102,808 | RP fighting blindness | The RP genome project | 听 |
| Khaw, Professor Sir Peng | 987,264 | National institute for health research | A novel biocompatible implant for glaukoma surgery: the biochannel device | 听 |
| Moosajee, Dr Mariya | 14,920 | Fight for sight | Identifying universal clefting genes that cause ocular and eyelid coloboma | 听 |
| van der Spuy, Dr Jacqui | 15,000 | Fight for sight | Supproting the triage of lca patients for aipl1-targeted gene therapy through the functional validation of uncharacterized and novel aipl1 variants | 听 |
| Bailly, Dr Maryse | 10,000 | Rosetrees trust | Research project studying characterisation of a novel marker for trachoma scarring and validation as a potential target for anti scarring treatments in the eye | 听 |
| Cheetham, Prof Mike | 170,000 | Fight for sight | Transplantation of human ipsc - derived photoreceptor progenitors into rodent retina to understand inherited retinal disease mechanisms and develop therapies | 听 |
| Daniels, Prof Julie | 100,000 | Fight for sight | S/ship tbc: development of therapeutic applications for corneal stromal stem cells | 听 |
| Garway-Heath, Prof Ted | 100,000 | Fight for sight | Which mechanisms confer resistance to glaukomatous neurodegeneration in ocular hypertention patients; relevance to neuroprotection | 听 |
| Levine, Dr Tim | 3,750 | F2g ltd | Studying novel start proteins to develop inhibitors that sensitise invasive fungi to amphotericin b | |
| Limb, Prof Astrid | 96,020 | Moorfields eye charity | Role of gliosis in the control of the regenerative ability of Muller stem cells in the adult human retina | 听 |
| Michaelides, Prof Michel | 139,265 | National institute for health research | Research funding award for research into achromatopsia | 听 |
| Pearson, Dr Rachael | 27,778 | Alcon research institute | Photoreceptor replacement therapy for the treatment of retinal retina degeneration | 听 |
| Yu Wai Man, Dr Patrick | 11,600 | National institute for health research | NIHR rare diseases translational research collaboration initiative: genotyping, phenotyping & informatics theme | 听 |
| Lengyel, Dr Imre | 39,930 | Moorfields eye hospital special trustees | Dominic Patel multimodal imaging of zinc in the human eye | 听 |
| Bailly, Dr Maryse | 18,500 | Moorfields eye hospital special trustees | Characterisation of a novel marker for trachoma scarring and validation as a potential target for anti-scarring treatments in the eye | 听 |
| Bailly, Dr Maryse | 100,000 | Fight for sight | The role of src family kinases in thyroid eye disease: disease mechanisms and therapeutic potential | 听 |
| Jeffery, Prof Glen | 75,000 | Kings college hospital nhs foundation trust | Using near infra red to modulate retinal atp and inflammation in age related macular degeneration | 听 |
| Bhattacharya, Prof Shomi | 18,000 | Moorfields eye hospital special trustees | Why do mutations in ubiquitously expressed genes result in a retina specific disease like retinitis pigmentosa | 听 |
| Lightman, Prof Susan | 253,750 | Moulton charitable trust | Can simvastatin significantly reduce the amount of immunosuppressive medication required by patients with sight threatening uveitis? | 听 |
| Michaelides, Prof Michel | 168,606 | Macular disease society | Assessing retinal structure and function longitudinally in stargardt disease using in-depth advanced phenotyping in preparation for planned therapeutic intervention | 听 |