香港六合彩中特网

Dr Hensman Moss undertook her PhD with Professor Sarah Tabrizi, at the 香港六合彩中特网 Huntington's Disease Centre, 香港六合彩中特网 Institute of Neurology.

Her research focuses on Huntington鈥檚 disease, which is an inherited condition caused by a faculty gene which affects the nervous system and can impact movement, learning, thinking and emotions. Specifically, Dr Hensman Moss is interested in why Huntington鈥檚 progresses more slowly in some people than in others, because knowing what modulates disease progression will provide targets for future therapies.听听

In the winning research paper, published in June 2017, she found that a version of a gene encoding for DNA repair affects the progression of Huntington鈥檚 disease. She explained to ARUK:

鈥淗untington鈥檚 disease is caused by an expansion mutation - a stretch of repetitive DNA which becomes too large, causing the Huntingtin protein to fold the wrong way which results in the disease. 鈥淲e believe that the DNA repair proteins cause this stretch of repetitive DNA to become even larger, and drive faster progression of the disease in some people.鈥�

Dr Hensman Moss further explained that successes in the field of Huntington鈥檚 disease can be beneficial to the wider field of dementia:

The genetic nature of Huntington鈥檚 disease makes it particularly devastating for families who have it, but also gives it some advantages when it comes to studying the disease. We know who has the disease, and who will get it in the future (if they have had the genetic test).

鈥淭his means we have been able to study the course of Huntington鈥檚 disease from its earliest stages to learn about how it changes over time in patients. There are drug trials underway using treatments that target this genetic error and the whole field of dementia awaits the results of these trials with great interest.鈥�

Source

Related

• Davina J Hensman Moss, Antonio F Pardi帽as, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, the TRACK-HD investigators, the REGISTRY investigators, Peter Holmans, Lesley Jones & Sarah J Tabrizi, ,鈥� Lancet Neurology. Available online 19 June 2017. DOI: 10.1016/S1474-4422(17)30161-8

听