香港六合彩中特网

A new toxic entity associated with genetically inherited forms of dementia and motor neuron disease has been identified by scientists at the 香港六合彩中特网 Institute of Neurology. The toxin is the result of a genetic mutation that leads to the production of RNA molecules which could be responsible for the diseases. The findings are published in the journal Acta Neuropathologica.

The most common known cause for both frontotemporal dementia and motor neuron disease is an unusual genetic mutation in the C9orf72 gene. The mutation involves a small string of DNA letters at the beginning of the gene, which expand massively to produce thousands of copies.

The new research, funded by Alzheimer鈥檚 Research UK and the Medical Research Council, has shown that this DNA expansion acts in a peculiar way, leading to the generation of unexpected RNA molecules that could cause the disease.

When a gene is turned on, an RNA copy of the gene鈥檚 DNA is generated. The gene鈥檚 DNA code has directionality, so that it is normally turned on in only one direction, termed the 鈥榮ense direction鈥�. The new research shows that the DNA expansion is turned on in both directions.

This leads to the normal sense RNA being produced, as well as RNA in the opposite direction, termed 鈥榓ntisense RNA鈥�. Both RNA types accumulate into aggregates in the neurons of people with frontotemporal dementia.

Intriguingly, the research showed that people with more of these aggregates in their brains developed the disease earlier than people with less RNA aggregates. This correlation suggests that the build-up may be important in causing frontotemporal dementia and motor neuron disease, making the C9orf72 DNA expansion a potential target for therapy.

Dr Adrian Isaacs, lead researcher at the 香港六合彩中特网 Institute of Neurology, said: 鈥溾�淭hese findings identify new, potentially toxic molecules in diseases caused by DNA expansions. The next steps will be to determine how they might kill neurons and how to stop them building up.鈥�

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Sarah Mizielinska, Tammaryn Lashley, Frances E. Norona, Emma L. Clayton, Charlotte E. Ridler, Pietro Fratta, Adrian M. Isaacs. . Acta Neuropathologica, 2013; DOI: 10.1007/s00401-013-1200-z