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Queen Square scientists question memory theory

15 November 2009

The long-held theory that our brains use different mechanisms for forming long-term and short-term memories has been challenged by new research from 香港六合彩中特网, published in PNAS.

Neuroscientists formed this theory based on observation of patients with amnesia, a condition that severely disrupts the ability to form long-lasting memories. Typically, amnesia is caused by injury to the hippocampi, a pair of brain structures located in the depth of the temporal lobes.

The team studied patients with a specific form of epilepsy called 鈥榯emporal lobe epilepsy with bilateral hippocampal sclerosis鈥, which leads to marked dysfunction of the hippocampi. They asked the patients to try and memorise photographic images depicting normal scenes, for example chairs and a table in a living-room. Their memory of the image was tested and brain activity recorded using MEG (magnetoencephalography) after a short interval of just five seconds, or a long interval of 60 minutes.

Nathan Cashdollar, (Department of Clinical and Experimental Epilepsy) first author of the paper, said: 鈥淩ecent behavioural observations had already begun challenging the classical distinction between long-term and short-term memory which has persisted for nearly half a century. However, this is the first functional and anatomical evidence showing which mechanisms are shared between short-term and long-term memory and which are independent.鈥

鈥淭hey also highlight that patients with impaired long-term memory have a short-term memory burden to carry in their daily life as well.鈥澛

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Reference >> Cashdollar,N., Malecki,U., Rugg-Gunn,F.J., Duncan,J.S., Lavie,N., Duzel,E. 鈥楬ippocampus dependent and independent theta-networks of active maintenance鈥 is published in the (PNAS)聽Monday 9th November聽online early edition.